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drk [cytosol]
Stable Identifier
R-DME-202367
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
GRAP2, Q08012
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
TCR signaling (Drosophila melanogaster)
Generation of second messenger molecules (Drosophila melanogaster)
Phosphorylation of PLC-gamma1 (Drosophila melanogaster)
ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Drosophila melanogaster)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Drosophila melanogaster)
GADS:p-5Y-LAT [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Drosophila melanogaster)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Drosophila melanogaster)
GADS:p-5Y-LAT [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Drosophila melanogaster)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Drosophila melanogaster)
GADS:p-5Y-LAT [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
DAP12 interactions (Drosophila melanogaster)
DAP12 signaling (Drosophila melanogaster)
Activation of RAC1 by VAV2/3 (Drosophila melanogaster)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)
GADS:SLP76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
GADS:SLP76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
GADS:SLP76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
GADS:SLP76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Release of p-PLCG1 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Autophosphorylation of BTK/ITK (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
FCERI mediated MAPK activation (Drosophila melanogaster)
Activation of RAC1 by VAV (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Autophosphorylation of PAK (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Phosphorylation and activation of VAV (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)
GADS:SLP76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
GADS:SLP76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
GADS:SLP76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
GADS:SLP76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of VAV to p-SLP-76 (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q08012
Gene Names
drk
Reference Genes
BioGPS Gene:36497 drk
CTD Gene:36497 drk
ENSEMBL:FBgn0004638
Flybase:FBgn0004638
KEGG Gene (Drosophila melanogaster):Dmel_CG6033 drk
Monarch:36497 drk
NCBI Gene:36497 drk
UCSC:Q08012 drk
Reference Transcript
RefSeq:NM_165998.2 drk
RefSeq:NM_165995.2 drk
RefSeq:NM_057510.4 drk
RefSeq:NM_165996.2 drk
RefSeq:NM_165994.2 drk
Other Identifiers
153747_at
1625475_s_at
36497
GO:0001784
GO:0005118
GO:0005154
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005886
GO:0007165
GO:0007173
GO:0007265
GO:0007426
GO:0007427
GO:0007465
GO:0007476
GO:0007605
GO:0007614
GO:0008022
GO:0008180
GO:0008286
GO:0008293
GO:0008306
GO:0008355
GO:0008543
GO:0009653
GO:0016020
GO:0016192
GO:0022414
GO:0023052
GO:0030154
GO:0030159
GO:0030707
GO:0032991
GO:0043226
GO:0043408
GO:0045202
GO:0045500
GO:0045793
GO:0048010
GO:0048260
GO:0048468
GO:0048513
GO:0048856
GO:0048870
GO:0050877
GO:0060090
GO:0060429
GO:0070374
GO:0098793
GO:1904263
Participates
as a component of
GADS:SLP76 [cytosol] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
GADS:p-5Y-LAT [plasma membrane] (Drosophila melanogaster)
Other forms of this molecule
drk [plasma membrane]
drk [cytosol]
Inferred From
GRAP2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_725304.1
,
NP_725302.1
,
NP_725303.1
,
NP_725306.1
,
NP_476858.1
Flybase
FBgn0004638
PRO
Q08012
PDB
7Y4N
,
2A37
,
2AZV
,
2A36
,
2AZS
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26675 Sos
4
SOS [cytosol]
(R-DME-205953)
phospho-Sos [cytosol]
(R-DME-109821)
Sos [cytosol]
(R-DME-167221)
Sos [cytosol]
(R-DME-64847)
0.692
3
UniProt:Q9VZZ9
9
phospho-dos [cytosol]
(R-DME-8855306)
phospho-dos [cytosol]
(R-DME-9677149)
phospho-dos [cytosol]
(R-DME-8855574)
phospho-dos [cytosol]
(R-DME-180496)
dos [cytosol]
(R-DME-508239)
phospho-dos [cytosol]
(R-DME-2685615)
phospho-dos [cytosol]
(R-DME-180344)
phospho-dos [cytosol]
(R-DME-912529)
dos [cytosol]
(R-DME-179795)
0.667
6
UniProt:Q9VWM7 Q9VWM7
0.488
2
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