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K63polyUb-IKBKG [cytosol]
Stable Identifier
R-DME-202530
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
Q9GYV5
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-1 signaling (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated NF-kB activation (Drosophila melanogaster)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
Ub-specific processing proteases (Drosophila melanogaster)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Drosophila melanogaster)
CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9GYV5 key
Gene Names
key, IKKGAMMA, CG16910
Chain
chain:1-387
Reference Genes
BioGPS Gene:37967 key
KEGG:dme:Dmel_CG16910 key
Monarch:37967 key
NCBI Gene:37967 key
UCSC:Q9GYV5 key
Reference Transcript
RefSeq:NM_079132.4 key
Other Identifiers
153921_at
1623762_at
37967
GO:0002230
GO:0002376
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006355
GO:0006955
GO:0006963
GO:0030163
GO:0043122
GO:0043226
GO:0045087
GO:0045089
GO:0045944
GO:0046872
GO:0050829
GO:0051607
GO:0061057
GO:0070530
GO:0098542
GO:2000647
Participates
as a member of
K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)
as a component of
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
Other forms of this molecule
KEY [cytosol]
OPTN [recycling endosome membrane]
IKBKG [nucleoplasm]
OPTN [Golgi membrane]
phospho-p-S177-OPTN [nucleoplasm]
phospho-p-S177-OPTN [cytosol]
IKBKG [cytosol]
OPTN [cytosol]
phospho-p-S177,S473,S513-OPTN [cytosol]
Inferred From
K63polyUb-IKBKG [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 321 (in Homo sapiens)
Coordinate
321
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 325 (in Homo sapiens)
Coordinate
325
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 326 (in Homo sapiens)
Coordinate
326
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_523856.2
ENSEMBL
FBtr0072428
,
FBpp0072333
FlyBase
FBgn0041205
PRO
Q9GYV5
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VEZ5 IKKbeta
8
IRD5 [cytosol]
(R-DME-206001)
Phospho IRD5 [cytosol]
(R-DME-206139)
phospho-p-Y187,Y198-CHUK [cytosol]
(R-DME-9861501)
phospho-p-T23-CHUK [cytosol]
(R-DME-198615)
phospho-p-S176,S180-CHUK [cytosol]
(R-DME-177667)
phospho-p-S177,S181-IKBKB [cytosol]
(R-DME-202506)
CHUK [cytosol]
(R-DME-168104)
IKBKB [cytosol]
(R-DME-168114)
0.632
4
UniProt:P34082
2
Fas2 [extracellular region]
(R-DME-8941043)
Fas2 [plasma membrane]
(R-DME-8940745)
0.527
2
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