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CACT [cytosol]
Stable Identifier
R-DME-205871
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Toll pathway (Drosophila melanogaster)
Degradation of NF-kappa-B inhibitor, CACT (Drosophila melanogaster)
DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' (Drosophila melanogaster)
DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
DL dimer:CACT [cytosol] (Drosophila melanogaster)
CACT [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT [plasma membrane] (Drosophila melanogaster)
DL dimer:CACT [cytosol] (Drosophila melanogaster)
CACT [cytosol] (Drosophila melanogaster)
DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
DL/DIF dimer:CACT [cytosol] (Drosophila melanogaster)
CACT [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:DL/DIF dimer:CACT [plasma membrane] (Drosophila melanogaster)
DL/DIF dimer:CACT [cytosol] (Drosophila melanogaster)
CACT [cytosol] (Drosophila melanogaster)
DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' (Drosophila melanogaster)
CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT [plasma membrane] (Drosophila melanogaster)
DL dimer:CACT [cytosol] (Drosophila melanogaster)
CACT [cytosol] (Drosophila melanogaster)
CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:DL/DIF dimer:CACT [plasma membrane] (Drosophila melanogaster)
DL/DIF dimer:CACT [cytosol] (Drosophila melanogaster)
CACT [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q03017 cact
Gene Names
cact, CG5848
Chain
chain:1-500
Reference Genes
BioGPS Gene:34969 cact
CTD Gene:34969 cact
KEGG:dme:Dmel_CG5848 cact
Monarch:34969 cact
NCBI Gene:34969 cact
UCSC:Q03017 cact
Reference Transcript
RefSeq:NM_057595.4 cact
RefSeq:NM_057594.4 cact
RefSeq:NM_001273567.1 cact
RefSeq:NM_165152.2 cact
RefSeq:NM_205999.2 cact
Other Identifiers
153684_at
1629899_at
1636926_s_at
34969
GO:0002376
GO:0002789
GO:0005515
GO:0005737
GO:0005829
GO:0006355
GO:0007253
GO:0007399
GO:0009950
GO:0009953
GO:0019730
GO:0022414
GO:0031594
GO:0043124
GO:0043226
GO:0045611
GO:0045751
GO:0046843
GO:0048477
GO:0048856
GO:0051059
GO:0051220
GO:0071212
GO:0071356
GO:0098542
GO:0140311
GO:0140313
Participates
as a component of
DL dimer:CACT [cytosol] (Drosophila melanogaster)
DL/DIF dimer:CACT [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Phospho CACT [cytosol]
cact [nucleoplasm]
phospho-cact [cytosol]
phospho-cact [cytosol]
cact [cytosol]
Cross References
RefSeq
NP_001260496.1
,
NP_476943.1
,
NP_476942.1
,
NP_995721.1
,
NP_723960.1
ENSEMBL
FBpp0080402
,
FBpp0080403
,
FBpp0089296
,
FBpp0308004
,
FBtr0080847
,
FBtr0337081
,
FBtr0080844
,
FBtr0080845
FlyBase
FBgn0000250
PRO
Q03017
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15330 dl
14
dl [nucleoplasm]
(R-DME-177676)
dl [cytosol]
(R-DME-168172)
dl [cytosol]
(R-DME-5607652)
dl [nucleoplasm]
(R-DME-5607656)
phospho-dl [nucleoplasm]
(R-DME-5624468)
phospho-dl [nucleoplasm]
(R-DME-5660642)
dl [cytosol]
(R-DME-1168579)
dl [nucleoplasm]
(R-DME-1168585)
dl [nucleoplasm]
(R-DME-4755466)
phospho-dl [nucleoplasm]
(R-DME-9861499)
dl [nucleoplasm]
(R-DME-8865233)
Phospho DL [nucleoplasm]
(R-DME-214731)
Phospho DL [cytosol]
(R-DME-214732)
DL [cytosol]
(R-DME-206011)
0.745
7
UniProt:Q9VR99
1
cactin [nucleoplasm]
(R-DME-9769591)
0.581
5
UniProt:Q9VEZ5 IKKbeta
8
IRD5 [cytosol]
(R-DME-206001)
Phospho IRD5 [cytosol]
(R-DME-206139)
phospho-p-Y187,Y198-CHUK [cytosol]
(R-DME-9861501)
phospho-p-T23-CHUK [cytosol]
(R-DME-198615)
phospho-p-S176,S180-CHUK [cytosol]
(R-DME-177667)
phospho-p-S177,S181-IKBKB [cytosol]
(R-DME-202506)
CHUK [cytosol]
(R-DME-168104)
IKBKB [cytosol]
(R-DME-168114)
0.544
2
UniProt:Q9V393 krz
10
krz [cytoplasmic vesicle membrane]
(R-DME-351187-3)
krz [Golgi membrane]
(R-DME-350831-3)
krz [lysosomal membrane]
(R-DME-432701-3)
krz [endocytic vesicle membrane]
(R-DME-9910881)
krz [endocytic vesicle membrane]
(R-DME-9910882-3)
krz [cytosol]
(R-DME-6783000)
krz [cytosol]
(R-DME-6783186-3)
Krz [cytosol]
(R-DME-2071841)
krz [cytosol]
(R-DME-416464)
krz [cytosol]
(R-DME-264470-3)
0.544
2
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