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FU [cytosol]
Stable Identifier
R-DME-205872
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Hedgehog pathway (Drosophila melanogaster)
N-HH ligand bound to PTC receptor complex (Drosophila melanogaster)
Activation of CI (Drosophila melanogaster)
Liberation of CI from SU(FU) repression (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Activation of SMO (Drosophila melanogaster)
Autophosphorylated FU phosphorylates COS (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Phospho (9 sites) Act SMO:COS:CI:FU [plasma membrane] (Drosophila melanogaster)
COS:CI:FU [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Phosphorylated SMO changes conformation and is activated (Drosophila melanogaster)
Phospho (9 sites) Act SMO:COS:CI:FU [plasma membrane] (Drosophila melanogaster)
COS:CI:FU [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Phospho (9 sites) SMO:COS:CI:FU [plasma membrane] (Drosophila melanogaster)
COS:CI:FU [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Phosphorylation of SMO (Drosophila melanogaster)
Phosphorylation of SMO by CKIalpha (Drosophila melanogaster)
Phospho (3 sites) SMO:COS:CI:FU [plasma membrane] (Drosophila melanogaster)
COS:CI:FU [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Phospho (9 sites) SMO:COS:CI:FU [plasma membrane] (Drosophila melanogaster)
COS:CI:FU [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Phosphorylation of SMO by PKA-C1 (Drosophila melanogaster)
Phospho (3 sites) SMO:COS:CI:FU [plasma membrane] (Drosophila melanogaster)
COS:CI:FU [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
SMO:COS:CI:FU [plasma membrane] (Drosophila melanogaster)
COS:CI:FU [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Assembly of the 'signalling complexes' (Drosophila melanogaster)
COS binds to SMO (Drosophila melanogaster)
COS:CI:FU [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
SMO:COS:CI:FU [plasma membrane] (Drosophila melanogaster)
COS:CI:FU [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
N-HH ligand not bound to PTC receptor complex (Drosophila melanogaster)
Assembly of the CI containing complexes (Drosophila melanogaster)
Formation of the 'scaffold complex' (Drosophila melanogaster)
COS:CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Phosphorylation of CI (Drosophila melanogaster)
Further phosphorylation of CI by CKIalphaepsilon (Drosophila melanogaster)
COS:Phospho (13 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
COS:Phospho (16 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO) (Drosophila melanogaster)
COS:Phospho (11 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
COS:Phospho (3 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Phosphorylation of CI by PKA-C1 (Drosophila melanogaster)
COS:CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
COS:Phospho (3 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Phosphorylation of CI by SGG (Drosophila melanogaster)
COS:Phospho (11 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
COS:Phospho (13 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Ubiquitination and proteolysis of phosphorylated CI (Drosophila melanogaster)
SLMB binds to and ubiquitinates phosphorylated CI (Drosophila melanogaster)
COS:Phospho (16 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:COS:Phospho (16 sites) CI:UBI-P63E:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:Phospho (16 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex (Drosophila melanogaster)
COS:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:COS:Phospho (16 sites) CI:UBI-P63E:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:Phospho (16 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
FU [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P23647 fu
Gene Names
fu, CG6551
Chain
chain:1-805
Reference Genes
BioGPS Gene:32855 fu
CTD Gene:32855 fu
KEGG Gene (Drosophila melanogaster):Dmel_CG6551 fu
Monarch:32855 fu
NCBI Gene:32855 fu
Reference Transcript
RefSeq:NM_058151.5 fu
Other Identifiers
143170_at
1635117_at
32855
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0005119
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0005929
GO:0006351
GO:0006355
GO:0006468
GO:0006913
GO:0007018
GO:0007224
GO:0007228
GO:0007293
GO:0007367
GO:0016301
GO:0016310
GO:0016740
GO:0022414
GO:0023052
GO:0030154
GO:0030514
GO:0031234
GO:0031398
GO:0032991
GO:0035222
GO:0035301
GO:0036211
GO:0042073
GO:0042803
GO:0043226
GO:0044782
GO:0045879
GO:0046777
GO:0046824
GO:0048856
GO:0106310
GO:0140096
Participates
as a component of
COS:CI:FU [cytosol] (Drosophila melanogaster)
COS:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:Phospho (3 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:Phospho (11 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:Phospho (13 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:Phospho (16 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
as an input of
Formation of the 'scaffold complex' (Drosophila melanogaster)
Other forms of this molecule
Phospho FU [cytosol]
Cross References
RefSeq
NP_477499.1
Flybase
FBgn0001079
PRO
P23647
PDB
6LPH
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O16844 cos
2
Phospho (2 sites) COS [cytosol]
(R-DME-206282)
COS [cytosol]
(R-DME-205832)
0.889
8
UniProt:P19538 ci
20
CI [nucleoplasm]
(R-DME-205911)
CI75 [nucleoplasm]
(R-DME-205741)
CI75 [cytosol]
(R-DME-206171)
CI [cytosol]
(R-DME-206046)
Phospho (3 sites) CI [cytosol]
(R-DME-205938)
Phospho (11 sites) CI [cytosol]
(R-DME-205757)
Phospho (13 sites) CI [cytosol]
(R-DME-205801)
Phospho (16 sites) CI [cytosol]
(R-DME-206294)
phospho-ci [nucleoplasm]
(R-DME-5635059)
phospho-ci [nucleoplasm]
(R-DME-5635060)
phospho-ci [ciliary base]
(R-DME-5610514)
ci [nucleoplasm]
(R-DME-5610371)
ci [cytosol]
(R-DME-5610369)
phospho-ci [ciliary base]
(R-DME-5610506)
phospho-ci [ciliary base]
(R-DME-5610485)
phospho-ci [ciliary base]
(R-DME-5610454)
phospho-ci [ciliary base]
(R-DME-5610492)
ci [ciliary base]
(R-DME-5610365)
ci [ciliary tip]
(R-DME-5610367)
ci [ciliary tip]
(R-DME-5610360)
0.784
9
UniProt:Q9XZH6
2
Vha13 [cytosol]
(R-DME-912578)
Vha13 [cytosol]
(R-DME-912588)
0.553
2
UniProt:P91682 smo
7
SMO [plasma membrane]
(R-DME-206086)
Phospho (3 sites) SMO [plasma membrane]
(R-DME-206009)
Phospho (9 sites) SMO [plasma membrane]
(R-DME-205802)
smo [ciliary membrane]
(R-DME-5624094)
smo [ciliary tip]
(R-DME-5610419)
smo [endocytic vesicle membrane]
(R-DME-5610422)
phospho-smo [ciliary membrane]
(R-DME-5632528)
0.527
5
UniProt:Q27279 Su(fu)
2
Phospho SU(FU) [cytosol]
(R-DME-205950)
SU(FU) [cytosol]
(R-DME-206064)
0.502
3
UniProt:Q9V853
4
Smurf [cytosol]
(R-DME-975972)
Smurf [cytosol]
(R-DME-173537)
Smurf [nucleoplasm]
(R-DME-3004548)
Smurf [nucleoplasm]
(R-DME-178202)
0.499
5
UniProt:Q95SI0 Q95SI0
0.499
4
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