Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
MTS [cytosol]
Stable Identifier
R-DME-206147
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Circadian Clock pathway (Drosophila melanogaster)
Dephosphorylation of PER (Drosophila melanogaster)
Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phosphorylation of PER and TIM (Drosophila melanogaster)
CRY is phosphorylated by SGG (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
PER is phosphorylated by DCO (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phosphorylated PER is phosphorylated by CK2 (Drosophila melanogaster)
RAS85D:GTP:SRC42A:Phospho CNK:14-3-3epsilon dimer:Phospho PHL:Phospho KSR:14-3-3epsilon dimer:AVE:DSOR1:CK2:PAR-1:PP2A [plasma membrane] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
TIM is phosphorylated by CK2 (Drosophila melanogaster)
RAS85D:GTP:SRC42A:Phospho CNK:14-3-3epsilon dimer:Phospho PHL:Phospho KSR:14-3-3epsilon dimer:AVE:DSOR1:CK2:PAR-1:PP2A [plasma membrane] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Hedgehog pathway (Drosophila melanogaster)
N-HH ligand bound to PTC receptor complex (Drosophila melanogaster)
Activation of SMO (Drosophila melanogaster)
Phosphorylation of SMO (Drosophila melanogaster)
Phosphorylation of SMO by CKIalpha (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phosphorylation of SMO by PKA-C1 (Drosophila melanogaster)
CNK:PHL:Phospho (2 sites) KSR:AVE:DSOR1:CK2:PAR-1:PP2A-29B:MTS [cytosol] (Drosophila melanogaster)
PP2A-29B:MTS [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
N-HH ligand not bound to PTC receptor complex (Drosophila melanogaster)
Assembly of the CI containing complexes (Drosophila melanogaster)
Phosphorylation of CI (Drosophila melanogaster)
Phosphorylation of CI by PKA-C1 (Drosophila melanogaster)
CNK:PHL:Phospho (2 sites) KSR:AVE:DSOR1:CK2:PAR-1:PP2A-29B:MTS [cytosol] (Drosophila melanogaster)
PP2A-29B:MTS [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phosphorylation of CI by SGG (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Ubiquitination and proteolysis of phosphorylated CI (Drosophila melanogaster)
SLMB binds to and ubiquitinates phosphorylated CI (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Wingless pathway (Drosophila melanogaster)
WG ligand bound to FZ receptors (Drosophila melanogaster)
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM (Drosophila melanogaster)
Destabilisation and degradation of AXN in the 'destruction complex' (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
WG ligand not bound to FZ receptors (Drosophila melanogaster)
Assembly of the 'destruction complex' (Drosophila melanogaster)
ARM binds to APC and AXN in the 'destruction complex' (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Formation of the 'destruction complex' (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phosphorylation of ARM (Drosophila melanogaster)
Further phosphorylation of ARM by SGG (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phospho ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phosphorylation of ARM by CKIalpha (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phospho ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phosphorylation of AXN and APC (Drosophila melanogaster)
Further phosphorylation of APC by DCO (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (2 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (5 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Further phosphorylation of APC by SGG (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (5 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phosphorylation of AXN and APC by DCO (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phosphorylation of AXN and APC by SGG (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (2 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
Ubiquitination and degradation of phosphorylated ARM (Drosophila melanogaster)
Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex' (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
SLMB binds to phosphorylated ARM to form the 'destruction complex' (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
MTS [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P23696 mts
Gene Names
mts, PP2A, Pp2A-28D, CG7109
Chain
chain:1-309
Reference Genes
BioGPS Gene:45959 mts
KEGG Gene (Drosophila melanogaster):Dmel_CG7109 mts
Monarch:45959 mts
NCBI Gene:45959 mts
Reference Transcript
RefSeq:NM_001298796.1 mts
RefSeq:NM_057457.4 mts
RefSeq:NM_001298795.1 mts
Other Identifiers
154353_at
1640841_at
45959
GO:0000159
GO:0000226
GO:0000278
GO:0001933
GO:0003824
GO:0004721
GO:0004722
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005814
GO:0005815
GO:0005829
GO:0005856
GO:0006470
GO:0006914
GO:0007010
GO:0007051
GO:0007059
GO:0007098
GO:0007099
GO:0007163
GO:0007168
GO:0007406
GO:0007460
GO:0007465
GO:0009416
GO:0016787
GO:0017018
GO:0019208
GO:0022414
GO:0023052
GO:0030154
GO:0035331
GO:0036211
GO:0043226
GO:0045752
GO:0045879
GO:0045880
GO:0046627
GO:0046872
GO:0048190
GO:0048477
GO:0048856
GO:0051225
GO:0051898
GO:0055059
GO:0090162
GO:0090263
GO:0090443
GO:0098772
GO:0140096
Participates
as a component of
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B:MTS [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
Other forms of this molecule
MTS [nucleoplasm]
MeL-PPP2CA [nucleoplasm]
phospho-p-Y307-PPP2CA [cytosol]
PPP2CA [nucleoplasm]
PPP2CA [cytosol]
Cross References
RefSeq
NP_001285725.1
,
NP_001285724.1
,
NP_476805.1
Flybase
FBgn0004177
PRO
P23696
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text