Further phosphorylation of APC by SGG

Stable Identifier
R-DME-209082
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Further phosphorylation of APC by SGG
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A Serine in APC (APC/APC2) is further phosphorylated by Shaggy (SGG). Ser1503 in Human APC is phosphorylated by GSK3beta.
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of Phospho (3 sites) AXN:Phospho (5 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol]

Physical Entity
Phospho (3 sites) AXN:Phospho (5 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Human APC is finally phosphorylated by Murine GSK3beta (Homo sapiens)
Authored
Williams, MG  (2006-07-26)
Reviewed
Nusse, R  (2008-01-19)
Created
Williams, MG  (2006-07-20)
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