Formation of the 'destruction complex'

Stable Identifier
R-DME-209133
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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The 'destruction complex' is formed from the large scaffolding proteins Axin (AXN) and APC (APC/APC2). This enables regulating molecules such as the kinases, CKIalpha, DCO, and Shaggy (SGG) and the phosphatase, PP2A to be held together in close proximity where they can regulate the phosphorylation of the scaffolding molecules and cytoplasmic Armadillo (ARM). The protein serine/threonine phosphatase PP2A is made up of the regulatory subunit A, PP2A-29B; the regulatory subunit B, Twins (TWS); and the catalytic subunit C, Microtubule star (MTS).
Literature References
PubMed ID Title Journal Year
10073940 Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin

Takatsu, Y, Shibuya, H, Nagai, S, Fujita, F, Ueno, N, Tomoyasu, Y, Akiyama, T, Toyoshima, K, Nakamura, M, Suzuki, A, Hamada, F

Science 1999
10838083 Biochemical characterization of the Drosophila axin protein

Yanagawa, S, Lee, JS, Matsuda, Y, Ishimoto, A

FEBS Lett 2000
10457025 A Drosophila Axin homolog, Daxin, inhibits Wnt signaling

Arora, A, Willert, K, Logan, CY, Nusse, R, Fish, M

Development 1999
8990193 A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo

Levine, AJ, Hayashi, S, Polakis, P, Souza, B, Wieschaus, E, Rubinfeld, B

Proc Natl Acad Sci U S A 1997
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