Reactome | CI transports from the cytosol to the nucleus

CI transports from the cytosol to the nucleus

Stable Identifier

R-DME-209163

Type

Reaction [transition]

Species

Drosophila melanogaster

Compartment

nuclear envelope

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

CI transports from the cytosol to the nucleus

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cubitus Interruptus (CI) access to the nucleus increases in response to Hedgehog signalling, most likely due to reduced cytoplasmic tethering by both Coastal2 (COS) and Suppressor of Fused (SU(FU)) complexes. However, the vast majority of CI is cytoplasmic.

Literature References

PubMed ID	Title	Journal	Year
15063184	Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms Wang, G, Jiang, J	Dev Biol	2004
11090136	Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus Wang, G, Wang, B, Jiang, J, Amanai, K	Genes Dev	2000
10862750	Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation Holmgren, RA, Wang, QT	Development	2000
14523402	Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog Therond, PP, Gallet, A, Lavenant-Staccini, L, Rodriguez, R, Ruel, L	Nat Cell Biol	2003
17925225	Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation Smelkinson, MG, Kalderon, D, Zhou, Q	Dev Cell	2007
10952898	Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus Basler, K, Methot, N	Development	2000
10458606	Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression Beachy, PA, Wang, B, Chen, CH, Park, W, von Kessler, DP, Ma, Y	Cell	1999
10529426	The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels Holmgren, RA, Wang, QT	Development	1999