Phosphorylation of CI by SGG

Stable Identifier
R-DME-209172
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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Previous phosphorylation of Cubitus Interruptus (CI) at Ser856 and Ser892 primes Shaggy (SGG) phosphorylation at Ser884 and Ser888. Ser852 can also be phosphorylated by SGG if it hasn't been previously phosphorylated by CKIalpha/DCO.

Literature References
PubMed ID Title Journal Year
11912487 Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

Jia, J, Amanai, K, Wang, G, Tang, J, Wang, B, Jiang, J

Nature 2002
16326393 Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing

Jia, J, Zhang, L, Zhang, Q, Tong, C, Wang, B, Hou, F, Amanai, K, Jiang, J

Dev Cell 2005
11955435 Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1

Price, MA, Kalderon, D

Cell 2002
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol]

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