Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane

Stable Identifier
R-DME-209185
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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Peptidoglycan recognition protein, PGRP-LCa receptor shows only a low affinity for monomeric peptidoglycans (PGN). However, when monomeric PGN binds to PGRP-LCx receptor primarily through its elongated stem peptide, the unique disaccharide GlcNAc-MurNAc(anhydro) residues of the ligand are then presented by PGRP-LCx receptor in such a way as to make favourable interactions with the PGRP-LCa receptor ectodomain. The receptors are now in close proximity and can heterodimerise.
Literature References
PubMed ID Title Journal Year
16556841 Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor

Chelliah, Y, Deisenhofer, J, Chang, CI, Borek, D, Mengin-Lecreulx, D

Science 2006
15843462 Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro

Hakansson, J, Mellroth, P, Schultz, N, Karlsson, J, Goldman, WE, Steiner, H

Proc Natl Acad Sci U S A 2005
16767093 PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan

Yano, T, Kaneko, T, Silverman, N, Lim, JH, Kurata, S, Peach, C, Oshima, Y, Aggarwal, K, Goldman, WE, Ueda, K, Erturk-Hasdemir, D, Oh, BH

Nat Immunol 2006
16006509 Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition

Wakatsuki, S, Chelliah, Y, Deisenhofer, J, Ihara, K, Chang, CI, Mengin-Lecreulx, D

Proc Natl Acad Sci U S A 2005
16428381 Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins

Yano, T, Silverman, N, Lim, JH, Kurata, S, Oshima, Y, Kim, HE, Aggarwal, K, Goldman, WE, Kim, MS, Oh, BH

J Biol Chem 2006
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