Reactome | Further phosphorylation of CI by CKIalphaepsilon

Further phosphorylation of CI by CKIalphaepsilon

Stable Identifier

R-DME-209187

Type

Reaction [transition]

Species

Drosophila melanogaster

Compartment

cytosol

ReviewStatus

5/5

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Further phosphorylation of CI by CKIalphaepsilon

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Previous phosphorylation of Cubitus Interruptus (CI) at Ser852 and Ser888 primes further phosphorylation by CKIalphaepsilon (CKIalpha/DCO) at Ser855, Ser858, and Ser891.

Literature References

PubMed ID	Title	Journal	Year
16326393	Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing Tong, C, Hou, F, Wang, B, Jiang, J, Zhang, L, Jia, J, Amanai, K, Zhang, Q	Dev Cell	2005
17925225	Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation Smelkinson, MG, Kalderon, D, Zhou, Q	Dev Cell	2007
11955435	Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1 Price, MA, Kalderon, D	Cell	2002

Participants

Input

Output

Participates

as an event of

Phosphorylation of CI (Drosophila melanogaster)

Catalyst Activity

protein serine/threonine kinase activity of CKIalphaepsilon [cytosol]

Physical Entity

CKIalphaepsilon [cytosol] (Drosophila melanogaster)

Activity

protein serine/threonine kinase activity (GO:0004674)

Authored

Williams, MG (2006-12-07)

Reviewed

Kalderon, D (2008-03-17)

Created

Williams, MG (2006-12-08)

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