Liberation of CI from SU(FU) repression

Stable Identifier
Reaction [transition]
Drosophila melanogaster
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Cubitus Interruptus (CI) that is spared from proteolysis is liberated from the repressive effects of its direct binding partner, Supressor of Fused (SU(FU)), by Fused (FU) Ser/Thr kinase activity. FU is believed to phosphorylate SU(FU) but it is not known if this relieves repression.

Literature References
PubMed ID Title Journal Year
10825151 Identification of a tetrameric hedgehog signaling complex

Stegman, MA, Vallance, JE, Elangovan, G, Sosinski, J, Cheng, Y, Robbins, DJ

J Biol Chem 2000
14636583 Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

Lum, L, Zhang, C, Oh, S, Mann, RK, von Kessler, DP, Taipale, J, Weis-Garcia, F, Gong, R, Wang, B, Beachy, PA

Mol Cell 2003
14523402 Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

Ruel, L, Rodriguez, R, Gallet, A, Lavenant-Staccini, L, Therond, PP

Nat Cell Biol 2003
15750186 Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused

Ho, KS, Suyama, K, Fish, M, Scott, MP

Development 2005
Catalyst Activity

protein serine/threonine kinase activity of FU [cytosol]

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