Liberation of CI from SU(FU) repression

Stable Identifier
R-DME-209220
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Liberation of CI from SU(FU) repression
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Cubitus Interruptus (CI) that is spared from proteolysis is liberated from the repressive effects of its direct binding partner, Supressor of Fused (SU(FU)), by Fused (FU) Ser/Thr kinase activity. FU is believed to phosphorylate SU(FU) but it is not known if this relieves repression.
Literature References
PubMed ID Title Journal Year
14636583 Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

Beachy, PA, Weis-Garcia, F, Oh, S, Wang, B, Lum, L, Zhang, C, Taipale, J, von Kessler, DP, Gong, R, Mann, RK

Mol Cell 2003
10825151 Identification of a tetrameric hedgehog signaling complex

Sosinski, J, Elangovan, G, Robbins, DJ, Cheng, Y, Vallance, JE, Stegman, MA

J Biol Chem 2000
14523402 Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

Therond, PP, Gallet, A, Lavenant-Staccini, L, Rodriguez, R, Ruel, L

Nat Cell Biol 2003
15750186 Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused

Ho, KS, Scott, MP, Fish, M, Suyama, K

Development 2005
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of FU [cytosol]

Physical Entity
FU [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2006-12-07)
Reviewed
Kalderon, D  (2008-03-17)
Created
Williams, MG  (2006-12-08)
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