Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5

Stable Identifier
R-DME-209240
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5
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IRD5 is phosphorylated and activated by phosphorylated TAK1 kinase at residues Thr217 and Ser221 in the activation loop.
Literature References
PubMed ID Title Journal Year
14519762 Immune activation of NF-kappaB and JNK requires Drosophila TAK1

Schneider, D, Silverman, N, Erlich, RL, Bernstein, E, Zhou, R, Hunter, M, Maniatis, T

J Biol Chem 2003
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of UEV1A:BEN:IAP2:UBI-P63E:TAB2:Phospho TAK1 [cytosol]

Physical Entity
UEV1A:BEN:IAP2:UBI-P63E:TAB2:Phospho TAK1 [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2007-07-11)
Reviewed
Lemaitre, B  (2008-06-20)
Silverman, N  (2008-06-20)
Created
Williams, MG  (2007-07-12)
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