Reactome | CI75 inhibits transcription

CI75 inhibits transcription

Stable Identifier

R-DME-209252

Type

Reaction [transition]

Species

Drosophila melanogaster

Compartment

nucleoplasm

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Upon arrival in the nucleus, truncated Cubitus Interruptus (CI75) represses transcription. Sensitive target genes include hh and dpp, but not ptc and repression depends on direct DNA-binding sites for CI75.

Literature References

PubMed ID	Title	Journal	Year
9215627	Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor Aza-Blanc, P, Ramirez-Weber, FA, Laget, MP, Schwartz, C, Kornberg, TB	Cell	1997
10102270	Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus Methot, N, Basler, K	Cell	1999
10862738	The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic gli-binding sites Müller, B, Basler, K	Development	2000