Phosphorylated STAT92E dimer activates transcription

Stable Identifier
R-DME-209307
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylated STAT92E dimer activates transcription
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Once in the nucleus, the phosphorylated STAT92E dimer binds to a palindromic DNA sequence in the promoters of the pathway target genes. This now enables transcription to be activated.
Literature References
PubMed ID Title Journal Year
8608596 Identification of a Stat gene that functions in Drosophila development

Small, S, Darnell JE, Jr, Desplan, C, Dearolf, CR, Yan, R

Cell 1996
9671298 Three-dimensional structure of the Stat3beta homodimer bound to DNA

Muller, CW, Becker, S, Groner, B

Nature 1998
16129580 Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E

Karsten, P, Perrimon, N, Zeidler, MP, Plischke, I

Cell Signal 2006
10823841 Constitutive activation of STAT5 by a point mutation in the SH2 domain

Nosaka, T, Ariyoshi, K, Miyajima, A, Onishi, M, Kitamura, T, Yamada, K, Oka, Y

J Biol Chem 2000
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Output
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Authored
Williams, MG  (2006-11-02)
Reviewed
Perrimon, N  (2008-01-16)
Created
Williams, MG  (2006-11-03)
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