Formation of the 'scaffold complex'

Stable Identifier
Reaction [binding]
Drosophila melanogaster
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The kinesin-related protein, Costal2 (COS), forms a microtubule-associated 'scaffold complex' with Cubitus Interruptus (CI) and the Ser/Thr protein kinase Fused (FU). CI also associates directly with the Supressor of Fused (SU(FU)) protein in a separate complex. Complexes containing CI, COS, FU and SU(FU) are detectable but rare. The Ser/Thr protein kinases: Protein kinase A (PKA-C1), Shaggy (SGG), Casein kinase I alpha (CKIalpha), and Casein kinase I epsilon (DCO) all bind to the scaffold protein COS.

Literature References
PubMed ID Title Journal Year
15691767 Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus

Zhang, W, Zhao, Y, Tong, C, Wang, G, Wang, B, Jia, J, Jiang, J

Dev Cell 2005
15063184 Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms

Wang, G, Jiang, J

Dev Biol 2004
14636583 Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

Lum, L, Zhang, C, Oh, S, Mann, RK, von Kessler, DP, Taipale, J, Weis-Garcia, F, Gong, R, Wang, B, Beachy, PA

Mol Cell 2003
11914126 Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2

Monnier, V, Ho, KS, Sanial, M, Scott, MP, Plessis, A

BMC Dev Biol 2002
11090136 Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

Wang, G, Amanai, K, Wang, B, Jiang, J

Genes Dev 2000
9601642 Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway

Monnier, V, Dussillol, F, Alves, G, Lamour-Isnard, C, Plessis, A

Curr Biol 1998
10825151 Identification of a tetrameric hedgehog signaling complex

Stegman, MA, Vallance, JE, Elangovan, G, Sosinski, J, Cheng, Y, Robbins, DJ

J Biol Chem 2000
11955435 Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1

Price, MA, Kalderon, D

Cell 2002
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