Phosphorylation of SMO by PKA-C1

Stable Identifier
R-DME-209341
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of SMO by PKA-C1
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The Ser/Thr kinase, Protein kinase A (PKA-C1) carries out priming phosphorylation of the transmembrane protein Smoothened (SMO) at Ser667, Ser687, and Ser740.
Literature References
PubMed ID Title Journal Year
15598741 Extensive phosphorylation of Smoothened in Hedgehog pathway activation

Williams, EH, Beachy, PA, Lum, L, Zhang, C, Guo, Y

Proc Natl Acad Sci U S A 2004
15592457 Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

Katanayeva, NM, Tomlinson, A, Apionishev, S, Kalderon, D, Marks, SA

Nat Cell Biol 2005
15616566 Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I

Tong, C, Wang, B, Jiang, J, Luo, L, Jia, J

Nature 2004
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of CNK:PHL:Phospho (2 sites) KSR:AVE:DSOR1:CK2:PAR-1:PP2A-29B:MTS [cytosol]

Physical Entity
CNK:PHL:Phospho (2 sites) KSR:AVE:DSOR1:CK2:PAR-1:PP2A-29B:MTS [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2006-12-07)
Reviewed
Kalderon, D  (2008-03-17)
Created
Williams, MG  (2006-12-08)
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