N-HH is palmitoylated by RASP

Stable Identifier
R-DME-209357
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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After removal of an N-terminal signal sequence, RASP, a protein-cysteine N-palmitoyltransferase, palmitoylates the new N-terminus (CGPGR..) via a thiol intermediate that resolves into a stable amide linkage. Palmitoylation efficiency is increased by prior addition of cholesterol at the C-terminus.

Literature References
PubMed ID Title Journal Year
11861468 Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling

Micchelli, CA, The, I, Selva, E, Mogila, V, Perrimon, N

Development 2002
15189162 Novel lipid modifications of secreted protein signals

Mann, RK, Beachy, PA

Annu Rev Biochem 2004
11486055 Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

Chamoun, Z, Mann, RK, Nellen, D, von Kessler, DP, Bellotto, M, Beachy, PA, Basler, K

Science 2001
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Catalyst Activity

palmitoyltransferase activity of RASP [cytosol]

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