Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription

Stable Identifier
R-DME-209358
Type
Reaction
Species
Drosophila melanogaster
Compartment
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The phosphorylated AP-1 transcription factor binds to its target genes and activates transcription. One of its target genes encodes the phosphatase Puckered (PUC) which acts as a negative regulator of the pathway as part of a negative feedback loop.

In the eye, another transcriptional target, arising from the Frizzled (FZ):Dishevelled (DSH) complex activation in R3 cells, is for the Notch (N) receptor ligand Delta (DL). This will subsequently bind to its receptor N in the neighbouring R4 cell.

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