Reactome | Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription

Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription

Stable Identifier

R-DME-209358

Type

Reaction

Species

Drosophila melanogaster

Compartment

nucleoplasm

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Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription

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The phosphorylated AP-1 transcription factor binds to its target genes and activates transcription. One of its target genes encodes the phosphatase Puckered (PUC) which acts as a negative regulator of the pathway as part of a negative feedback loop.

In the eye, another transcriptional target, arising from the Frizzled (FZ):Dishevelled (DSH) complex activation in R3 cells, is for the Notch (N) receptor ligand Delta (DL). This will subsequently bind to its receptor N in the neighbouring R4 cell.

Literature References

PubMed ID	Title	Journal	Year
10903185	Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye Paricio, N, Mlodzik, M, Weber, U	Development	2000
11865058	CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila Marinissen, MJ, Hou, SX, Chen, X, Chen, HW, Oh, SW, Gutkind, JS, Melnick, M, Perrimon, N	Mol Cell Biol	2002
7816143	Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA Glover, JN, Harrison, SC	Nature	1995
10572048	Decoding vectorial information from a gradient: sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye Struhl, G, Tomlinson, A	Development	1999
10028968	Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye Fanto, M, Mlodzik, M	Nature	1999

Participants

Input

Phospho JRA:Phospho KAY [nucleoplasm] (Drosophila melanogaster)

Output

Phospho JRA:Phospho KAY [nucleoplasm] (Drosophila melanogaster)

Participates

as an event of

Transcriptional activtion by AP-1 transcription factor (Drosophila melanogaster)

Authored

Williams, MG (2007-07-11)

Reviewed

Lemaitre, B (2008-06-20)

Silverman, N (2008-06-20)

Created

Williams, MG (2007-07-12)