Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 2

Stable Identifier
R-DME-210694
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
An alternative spliced form of the protein tyrosine phosphatase, PTP61FC (PTP61F isoform 2) is active in the nucleus and dephosphorylates the phosphorylated STAT92E dimer on Tyr711 resulting in its dissociation.
Literature References
PubMed ID Title Journal Year
16094372 Identification of JAK/STAT signalling components by genome-wide RNA interference

Kuttenkeuler, D, Boutros, M, Zeidler, MP, Müller, P, Gesellchen, V

Nature 2005
8463208 Alternative splicing gives rise to a nuclear protein tyrosine phosphatase in Drosophila

Dixon, JE, McLaughlin, S

J Biol Chem 1993
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine phosphatase activity of PTP61F isoform 2 [nucleoplasm]

Physical Entity
PTP61F isoform 2 [nucleoplasm] (Drosophila melanogaster)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Authored
Williams, MG  (2006-11-02)
Reviewed
Perrimon, N  (2008-01-16)
Created
Williams, MG  (2008-01-15)
Cite Us!