Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
E(z) [nucleoplasm]
Stable Identifier
R-DME-212298
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
EZH2, P42124
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular Senescence (Drosophila melanogaster)
Oxidative Stress Induced Senescence (Drosophila melanogaster)
Formation of PRC2-EZH2 complex (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
Epigenetic regulation of gene expression (Drosophila melanogaster)
PRC2 methylates histones and DNA (Drosophila melanogaster)
DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Drosophila melanogaster)
DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Drosophila melanogaster)
PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Drosophila melanogaster)
PRC2 Core:Chromatin [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2 trimethylates histone H3 at lysine-27 (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:Chromatin (H3K27me3) [nucleoplasm] (Drosophila melanogaster)
PRC2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:JARID2:MTF2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF1 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF19 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:Chromatin [nucleoplasm] (Drosophila melanogaster)
PRC2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:JARID2:MTF2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF1 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF19 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Drosophila melanogaster)
PRC2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:JARID2:MTF2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF1 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF19 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:Chromatin [nucleoplasm] (Drosophila melanogaster)
PRC2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:JARID2:MTF2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF1 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF19 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by E2F6 (Drosophila melanogaster)
E2F6:TFDP1:EPC1 binds the PRC2 complex (Drosophila melanogaster)
E2F6:TFDP1:EPC1:PRC2 (EZH2) core [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
PTEN Regulation (Drosophila melanogaster)
Regulation of PTEN gene transcription (Drosophila melanogaster)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Drosophila melanogaster)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Drosophila melanogaster)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Drosophila melanogaster)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
E(z) [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P42124
Gene Names
E(z)
Reference Genes
BioGPS Gene:39203 E(z)
ENSEMBL:FBgn0000629
Flybase:FBgn0000629
KEGG Gene (Drosophila melanogaster):Dmel_CG6502 E(z)
Monarch:39203 E(z)
NCBI Gene:39203 E(z)
Reference Transcript
RefSeq:NM_001144460.3 E(z)
RefSeq:NM_079297.3 E(z)
Other Identifiers
154532_at
1626696_at
39203
GO:0000278
GO:0000785
GO:0003677
GO:0003682
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0007411
GO:0008168
GO:0009948
GO:0016740
GO:0022008
GO:0030154
GO:0031507
GO:0032259
GO:0035097
GO:0035098
GO:0035186
GO:0036211
GO:0042054
GO:0043226
GO:0043229
GO:0043565
GO:0045892
GO:0046974
GO:0046976
GO:0048856
GO:0070734
GO:0098532
GO:0140096
GO:0140718
GO:0140951
GO:1902692
Participates
as an input of
Formation of PRC2-EZH2 complex (Drosophila melanogaster)
as a component of
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Inferred From
EZH2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_524021.2
,
NP_001137932.1
Flybase
FBgn0000629
IntEnz
2.1.1.356
ZINC target
P42124
PRO
P42124
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q24338 ESC
0.964
22
UniProt:Q24459 PCL
0.847
15
UniProt:Q24572
1
Caf1-55 [nucleoplasm]
(R-DME-212223)
0.833
7
UniProt:Q94517 Rpd3
3
RPD3 [nucleoplasm]
(R-DME-354293)
HDAC1 [nucleoplasm]
(R-DME-205021)
HDAC1 [nucleoplasm]
(R-DME-205135)
0.783
9
UniProt:Q9VEX9
1
Bin1 [nucleoplasm]
(R-DME-351694)
0.633
7
UniProt:Q9NJG9
1
Su(z)12 [nucleoplasm]
(R-DME-212217)
0.527
2
UniProt:P41046 CORTO
0.508
2
UniProt:Q95SW6 Q95SW6
0.499
2
UniProt:Q9VDY1
1
INO80 [nucleoplasm]
(R-DME-5688910)
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text