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gro [nucleoplasm]
Stable Identifier
R-DME-212327
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
TLE1, P16371
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
Degradation of beta-catenin by the destruction complex (Drosophila melanogaster)
Repression of WNT target genes (Drosophila melanogaster)
TLE oligomerizes (Drosophila melanogaster)
TLE tetramer [nucleoplasm] (Drosophila melanogaster)
TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
gro [nucleoplasm] (Drosophila melanogaster)
gro [nucleoplasm] (Drosophila melanogaster)
TLE tetramers bind TCF/LEF at WNT promoters (Drosophila melanogaster)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Drosophila melanogaster)
TLE tetramer [nucleoplasm] (Drosophila melanogaster)
TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
gro [nucleoplasm] (Drosophila melanogaster)
TLE tetramer [nucleoplasm] (Drosophila melanogaster)
TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
gro [nucleoplasm] (Drosophila melanogaster)
TCF dependent signaling in response to WNT (Drosophila melanogaster)
Deactivation of the beta-catenin transactivating complex (Drosophila melanogaster)
XIAP binds TLE (Drosophila melanogaster)
TLE tetramer [nucleoplasm] (Drosophila melanogaster)
TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
gro [nucleoplasm] (Drosophila melanogaster)
TLE:XIAP [nucleoplasm] (Drosophila melanogaster)
TLE tetramer [nucleoplasm] (Drosophila melanogaster)
TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
gro [nucleoplasm] (Drosophila melanogaster)
XIAP monoubiquinates TLE (Drosophila melanogaster)
TLE:XIAP [nucleoplasm] (Drosophila melanogaster)
TLE tetramer [nucleoplasm] (Drosophila melanogaster)
TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
gro [nucleoplasm] (Drosophila melanogaster)
beta-catenin is replaced by repression complexes at the promoter (Drosophila melanogaster)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Drosophila melanogaster)
TLE:HDAC1 [nucleoplasm] (Drosophila melanogaster)
TLE tetramer [nucleoplasm] (Drosophila melanogaster)
TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
gro [nucleoplasm] (Drosophila melanogaster)
TLE1:HDAC1 [nucleoplasm] (Drosophila melanogaster)
TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
gro [nucleoplasm] (Drosophila melanogaster)
Formation of the beta-catenin:TCF transactivating complex (Drosophila melanogaster)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Drosophila melanogaster)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Drosophila melanogaster)
TLE:HDAC1 [nucleoplasm] (Drosophila melanogaster)
TLE tetramer [nucleoplasm] (Drosophila melanogaster)
TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
gro [nucleoplasm] (Drosophila melanogaster)
TLE tetramer [nucleoplasm] (Drosophila melanogaster)
TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
gro [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P16371 gro
Gene Names
gro, E(spl)m9/m10, CG8384
Chain
chain:1-730
Reference Genes
BioGPS Gene:43162 gro
KEGG Gene (Drosophila melanogaster):Dmel_CG8384 gro
Monarch:43162 gro
NCBI Gene:43162 gro
UCSC:P16371 gro
Reference Transcript
RefSeq:NM_206575.3 gro
RefSeq:NM_170255.4 gro
RefSeq:NM_170256.2 gro
RefSeq:NM_170254.3 gro
RefSeq:NM_079790.5 gro
RefSeq:NM_001202364.1 gro
Other Identifiers
142039_s_at
43162
GO:0000003
GO:0000122
GO:0003674
GO:0003714
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005667
GO:0006355
GO:0007165
GO:0007173
GO:0007267
GO:0007275
GO:0007399
GO:0007541
GO:0008134
GO:0008150
GO:0008293
GO:0008543
GO:0009058
GO:0016055
GO:0030154
GO:0032991
GO:0034641
GO:0043226
GO:0045751
GO:0045892
GO:0048856
GO:0070491
GO:0071837
GO:0071906
GO:0090090
Participates
as an input of
TLE oligomerizes (Drosophila melanogaster)
as a component of
TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
Other forms of this molecule
GRO [nucleoplasm]
gro [nucleoplasm]
gro [nucleoplasm]
gro [nucleoplasm]
gro [nucleoplasm]
gro [nucleoplasm]
gro [nucleoplasm]
gro [nucleoplasm]
Inferred From
TLE [nucleoplasm]
(Homo sapiens)
TLE1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_733135.1
,
NP_733134.1
,
NP_996298.1
,
NP_733133.1
,
NP_524514.2
,
NP_001189293.1
Flybase
FBgn0001139
PRO
P16371
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14003 HAIR
0.819
7
UniProt:Q01071 ESMD
0.668
4
UniProt:P10734
20
kni [cytosol]
(R-DME-9020968)
kni [nucleoplasm]
(R-DME-446168)
kni [nucleoplasm]
(R-DME-3196163)
kni [cytosol]
(R-DME-5618082)
kni [nucleoplasm]
(R-DME-446174)
kni [cytosol]
(R-DME-9632177)
kni [plasma membrane]
(R-DME-9637786)
kni [plasma membrane]
(R-DME-9637788)
kni [plasma membrane]
(R-DME-9021053)
kni [plasma membrane]
(R-DME-9021057)
kni [cytosol]
(R-DME-9020991)
kni [cytosol]
(R-DME-9020974)
kni [nucleoplasm]
(R-DME-3008952)
kni [nucleoplasm]
(R-DME-446159)
kni [cytosol]
(R-DME-5618122)
kni [cytosol]
(R-DME-8948964)
kni [cytosol]
(R-DME-5618118)
kni [nucleoplasm]
(R-DME-3008717)
kni [nucleoplasm]
(R-DME-3196152)
kni [nucleoplasm]
(R-DME-3196155)
0.653
5
UniProt:P13098 ESM8
0.553
4
UniProt:Q01068 ESM3
0.553
4
UniProt:P13096 ESM5
0.553
3
UniProt:P91943 pan
1
PAN [nucleoplasm]
(R-DME-205730)
0.553
3
UniProt:Q62233 SIX3
0.544
2
UniProt:Q9W4S7
2
Myc [nucleoplasm]
(R-DME-452357)
Myc [nucleoplasm]
(R-DME-188379)
0.524
3
UniProt:O97102
6
Sumo [nucleoplasm]
(R-DME-2990830)
Sumo [nucleoplasm]
(R-DME-2984269)
Sumo [nucleoplasm]
(R-DME-3730611)
Sumo [nucleoplasm]
(R-DME-2990837)
Sumo [nucleoplasm]
(R-DME-2984281)
Sumo [nucleoplasm]
(R-DME-3730625)
0.524
2
UniProt:Q27350 SO
0.502
2
UniProt:Q26263 DPN
0.502
2
UniProt:P54366 GSC
0.502
2
UniProt:P22814
20
run [plasma membrane]
(R-DME-5667138-2)
run [nucleoplasm]
(R-DME-8952417-2)
phospho-run [cytosol]
(R-DME-8937805-2)
run [nucleoplasm]
(R-DME-8952387-2)
run [cytosol]
(R-DME-8952400-2)
run [nucleoplasm]
(R-DME-8951965-2)
phospho-run [nucleoplasm]
(R-DME-8939964-2)
phospho-run [nucleoplasm]
(R-DME-9014875-2)
phospho-run [nucleoplasm]
(R-DME-8878063-2)
phospho-run [nucleoplasm]
(R-DME-8937712-2)
run [nucleoplasm]
(R-DME-8865393-2)
run [cytosol]
(R-DME-8937797-2)
run [nucleoplasm]
(R-DME-9007691-2)
run [nucleoplasm]
(R-DME-9007689-2)
run [cytosol]
(R-DME-9007987-2)
run [cytosol]
(R-DME-9007983-2)
phospho-run [nucleoplasm]
(R-DME-9009192-2)
phospho-run [nucleoplasm]
(R-DME-9009188-2)
phospho-run [nucleoplasm]
(R-DME-9008422-2)
phospho-run [nucleoplasm]
(R-DME-9008409-2)
0.502
2
UniProt:Q01196-1 RUNX1
0.488
4
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