Reactome | gro [nucleoplasm]

gro [nucleoplasm]

Stable Identifier

R-DME-212327

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

TLE1, P16371

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Drosophila melanogaster)

- Cell junction organization (Drosophila melanogaster)
  - Cell-cell junction organization (Drosophila melanogaster)
    - Adherens junctions interactions (Drosophila melanogaster)
      - Regulation of Homotypic Cell-Cell Adhesion (Drosophila melanogaster)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Drosophila melanogaster)
        
        Regulation of CDH1 Expression and Function (Drosophila melanogaster)
        
        Regulation of CDH1 Gene Transcription (Drosophila melanogaster)
        
        Negative Regulation of CDH1 Gene Transcription (Drosophila melanogaster)
        
        ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter (Drosophila melanogaster)
        
        HDAC1,(HDAC2):TLE1:ZEB1:CDH1 gene [nucleoplasm] (Drosophila melanogaster)
        
        TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
        
        gro [nucleoplasm] (Drosophila melanogaster)
        
        TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)
        
        gro [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P16371 gro

Gene Names

gro, E(spl)m9/m10, CG8384

Chain

chain:1-730

Reference Genes

BioGPS Gene:43162 gro

KEGG:dme:Dmel_CG8384 gro

Monarch:43162 gro

NCBI Gene:43162 gro

UCSC:P16371 gro

Reference Transcript

Other Identifiers

142039_s_at

142820_at

1636141_s_at

43162

GO:0000122

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0006355

GO:0007173

GO:0007399

GO:0007541

GO:0008293

GO:0008543

GO:0016055

GO:0022414

GO:0030154

GO:0032991

GO:0043226

GO:0045751

GO:0045892

GO:0048856

GO:0060090

GO:0071837

GO:0071906

GO:0090090

GO:0140110

GO:0140297

Participates

as an input of

TLE oligomerizes (Drosophila melanogaster)

as a component of

TLE1 tetramer [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

GRO [nucleoplasm]

gro [nucleoplasm]

Inferred From

TLE [nucleoplasm] (Homo sapiens)

TLE1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_996298.1, NP_524514.2, NP_733134.1, NP_733135.1, NP_733133.1, NP_001189293.1

ENSEMBL

FBpp0089115, FBgn0001139, FBtr0084966

FlyBase

FBgn0001139

PRO

P16371

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14003 HAIR			0.819	7
UniProt:Q01071 ESMD			0.668	4
UniProt:P10734	20	kni [cytosol] (R-DME-9020968) kni [cytosol] (R-DME-9020970) kni [nucleoplasm] (R-DME-3196163) kni [nucleoplasm] (R-DME-446168) kni [nucleoplasm] (R-DME-446165) kni [nucleoplasm] (R-DME-3008952) kni [nucleoplasm] (R-DME-446159) kni [nucleoplasm] (R-DME-446174) kni [cytosol] (R-DME-5618082) kni [cytosol] (R-DME-9632177) kni [cytosol] (R-DME-9020991) kni [cytosol] (R-DME-9020979) kni [cytosol] (R-DME-9020974) kni [plasma membrane] (R-DME-9021053) kni [plasma membrane] (R-DME-9021059) kni [plasma membrane] (R-DME-9021057) kni [plasma membrane] (R-DME-9637787) kni [plasma membrane] (R-DME-9637786) kni [plasma membrane] (R-DME-9637788) kni [nucleoplasm] (R-DME-3196152)	0.653	5
UniProt:P13098 ESM8			0.553	4
UniProt:Q01068 ESM3			0.553	4
UniProt:P13096 ESM5			0.553	3
UniProt:P91943 pan	1	PAN [nucleoplasm] (R-DME-205730)	0.553	3
UniProt:Q62233 SIX3			0.544	2
UniProt:O97102	6	Sumo [nucleoplasm] (R-DME-2990830) Sumo [nucleoplasm] (R-DME-3730611) Sumo [nucleoplasm] (R-DME-2984269) Sumo [nucleoplasm] (R-DME-2990837) Sumo [nucleoplasm] (R-DME-2984281) Sumo [nucleoplasm] (R-DME-3730625)	0.524	2
UniProt:Q9W4S7	2	Myc [nucleoplasm] (R-DME-452357) Myc [nucleoplasm] (R-DME-188379)	0.524	3
UniProt:Q27350 SO			0.502	2
UniProt:Q26263 DPN			0.502	2
UniProt:P54366 GSC			0.502	2
UniProt:P22814	20	run [plasma membrane] (R-DME-5667138) phospho-run [nucleoplasm] (R-DME-8878063) phospho-run [nucleoplasm] (R-DME-8937712) run [nucleoplasm] (R-DME-8934750) run [nucleoplasm] (R-DME-8865295) run [nucleoplasm] (R-DME-8865393-2) run [cytosol] (R-DME-8937797-2) run [nucleoplasm] (R-DME-9007691-2) run [nucleoplasm] (R-DME-9007689-2) run [cytosol] (R-DME-9007987-2) run [cytosol] (R-DME-9007983-2) phospho-run [nucleoplasm] (R-DME-9008422-2) phospho-run [nucleoplasm] (R-DME-9008409-2) phospho-run [nucleoplasm] (R-DME-9009192-2) phospho-run [nucleoplasm] (R-DME-9009188-2) phospho-run [nucleoplasm] (R-DME-9008847-2) phospho-run [nucleoplasm] (R-DME-9008852-2) run [cytosol] (R-DME-9008086-2) run [cytosol] (R-DME-9008082-2) run [nucleoplasm] (R-DME-9008124-2)	0.502	2
UniProt:Q01196-1 RUNX1			0.488	4