Reactome | CycC [nucleoplasm]

CycC [nucleoplasm]

Stable Identifier

R-DME-212418

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

CCNC, P25008

Locations in the PathwayBrowser

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Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Drosophila melanogaster)
        
        CDK8:CCNC [nucleoplasm] (Drosophila melanogaster)
        
        CycC [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by TGFB family members (Drosophila melanogaster)
  - Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Drosophila melanogaster)
        
        CDK8:CCNC [nucleoplasm] (Drosophila melanogaster)
        
        CycC [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P25008

Gene Names

CycC

Reference Genes

BioGPS Gene:41801 CycC

ENSEMBL:FBgn0004597

Flybase:FBgn0004597

KEGG Gene (Drosophila melanogaster):Dmel_CG7281 CycC

Monarch:41801 CycC

NCBI Gene:41801 CycC

Reference Transcript

RefSeq:NM_057500.4 CycC

Other Identifiers

154741_at

1630405_at

41801

GO:0003712

GO:0005515

GO:0005634

GO:0006351

GO:0006355

GO:0006357

GO:0006914

GO:0010508

GO:0016073

GO:0016538

GO:0016592

GO:0022416

GO:0034472

GO:0036011

GO:0043226

GO:0045498

GO:0045944

GO:0048856

GO:0098772

GO:0140110

Participates

as a component of

CDK8:CCNC [nucleoplasm] (Drosophila melanogaster)

Inferred From

CCNC [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_476848.1

Flybase

FBgn0004597

PRO

P25008

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23572	9	phospho-p-Y4-CDK1 [cytosol] (R-DME-9836187) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-DME-170078) phospho-p-T14-CDK1 [nucleoplasm] (R-DME-170045) phospho-p-T14-CDK1 [cytosol] (R-DME-170064) CDK1 [cytosol] (R-DME-170075) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-DME-170071) phospho-p-T161-CDK1 [cytosol] (R-DME-157415) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-DME-170074) phospho-p-T161-CDK1 [nucleoplasm] (R-DME-170066)	0.621	4

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