Reactome | Cdk8 [nucleoplasm]

Cdk8 [nucleoplasm]

Stable Identifier

R-DME-212440

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

CDK8, Q9VT57

Locations in the PathwayBrowser

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Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Drosophila melanogaster)
        
        CDK8:CCNC [nucleoplasm] (Drosophila melanogaster)
        
        Cdk8 [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by TGFB family members (Drosophila melanogaster)
  - Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Drosophila melanogaster)
        
        CDK8:CCNC [nucleoplasm] (Drosophila melanogaster)
        
        Cdk8 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VT57

Gene Names

Cdk8

Reference Genes

BioGPS Gene:39157 Cdk8

ENSEMBL:FBgn0015618

Flybase:FBgn0015618

KEGG Gene (Drosophila melanogaster):Dmel_CG10572 Cdk8

Monarch:39157 Cdk8

NCBI Gene:39157 Cdk8

Reference Transcript

RefSeq:NM_080487.4 Cdk8

Other Identifiers

142743_at

1630579_at

39157

GO:0000082

GO:0000166

GO:0000278

GO:0003674

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006464

GO:0006468

GO:0006914

GO:0007049

GO:0008150

GO:0008353

GO:0009056

GO:0010508

GO:0016301

GO:0016310

GO:0016592

GO:0016740

GO:0022416

GO:0032991

GO:0034472

GO:0034641

GO:0036011

GO:0043167

GO:0043226

GO:0045498

GO:0048856

GO:0051726

GO:0106310

GO:0106311

Participates

as a component of

CDK8:CCNC [nucleoplasm] (Drosophila melanogaster)

Inferred From

CDK8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_536735.2

Flybase

FBgn0015618

IntEnz

2.7.11.23

PRO

Q9VT57

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