Monomeric PGN bound PGRP-LE oligomerises in the cytosol

Stable Identifier
R-DME-214395
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
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The binding of monomeric peptidoglycans (PGN) to PGRP-LE receptor results in adjacent PGRP-LE receptors binding to the complex and forming a PGRP-LE oligomer.

Literature References
PubMed ID Title Journal Year
16428381 Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins

Yano, T, Silverman, N, Lim, JH, Kurata, S, Oshima, Y, Kim, HE, Aggarwal, K, Goldman, WE, Kim, MS, Oh, BH

J Biol Chem 2006
16767093 PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan

Yano, T, Kaneko, T, Silverman, N, Lim, JH, Kurata, S, Peach, C, Oshima, Y, Aggarwal, K, Goldman, WE, Ueda, K, Erturk-Hasdemir, D, Oh, BH

Nat Immunol 2006
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