Reactome | DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex'

DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex'

Stable Identifier

R-DME-214880

Type

Reaction [binding]

Species

Drosophila melanogaster

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex'

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In dorsoventral patterning in the embryo, Dorsal (DL) homodimers in complex with the NF-kappaB inhibitor orthologue, Cactus (CACT), bind to the adaptor proteins Tube (TUB) and phosphorylated Pelle (PLL) in the receptor 'signalling complex' at the plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
9405646	A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal Steward, R, Yang, J	Proc Natl Acad Sci U S A	1997
9367441	An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators Wasserman, SA, Towb, P, Edwards, DN	Development	1997

Participants

Input

Output

SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT [plasma membrane] (Drosophila melanogaster)

Participates

as an event of

DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' (Drosophila melanogaster)

Authored

Williams, MG (2007-07-11)

Reviewed

Lemaitre, B (2008-06-20)

Silverman, N (2008-06-20)

Created

Williams, MG (2008-02-26)

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