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DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex'
Stable Identifier
R-DME-214880
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Drosophila signaling pathways (Drosophila melanogaster)
Toll pathway (Drosophila melanogaster)
Degradation of NF-kappa-B inhibitor, CACT (Drosophila melanogaster)
DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' (Drosophila melanogaster)
DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
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In dorsoventral patterning in the embryo, Dorsal (DL) homodimers in complex with the NF-kappaB inhibitor orthologue, Cactus (CACT), bind to the adaptor proteins Tube (TUB) and phosphorylated Pelle (PLL) in the receptor 'signalling complex' at the plasma membrane.
Literature References
PubMed ID
Title
Journal
Year
9405646
A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal
Steward, R
,
Yang, J
Proc Natl Acad Sci U S A
1997
9367441
An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators
Wasserman, SA
,
Towb, P
,
Edwards, DN
Development
1997
Participants
Input
DL dimer:CACT [cytosol]
(Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane]
(Drosophila melanogaster)
Output
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT [plasma membrane]
(Drosophila melanogaster)
Participates
as an event of
DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' (Drosophila melanogaster)
Authored
Williams, MG (2007-07-11)
Reviewed
Lemaitre, B (2008-06-20)
Silverman, N (2008-06-20)
Created
Williams, MG (2008-02-26)
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