Dissociation of CI from COS

Stable Identifier
R-DME-216133
Type
Reaction [dissociation]
Species
Drosophila melanogaster
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Coastal2 (COS) phosphorylated on Ser572 has reduced affinity for Cubitus Interruptus (CI). This may contribute to partial dissociation of CI from COS complexes.

Literature References
PubMed ID Title Journal Year
17881487 Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling

Ruel, L, Gallet, A, Raisin, S, Truchi, A, Staccini-Lavenant, L, Cervantes, A, Therond, PP

Development 2007
17671093 Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation

Liu, Y, Cao, X, Jiang, J, Jia, J

Genes Dev 2007
Participants
Participates
Authored
Reviewed
Created
Cite Us!