Ubiquitinated CI is degraded by the proteasome complex

Stable Identifier
R-DME-216282
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The ubiquitinated Cubitus Interruptus (CI) is marked for degradation in the nucleus by the 26S proteasome complex.
Literature References
PubMed ID Title Journal Year
16651542 Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus

Hooper, JE, Bush, EW, Kent, D

Development 2006
17102630 Regulation of Hh/Gli signaling by dual ubiquitin pathways

Jiang, J

Cell Cycle 2006
16740475 A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor

Ou, CY, Wang, B, Jiang, J, Chien, CT, Zhang, L, Zhang, Q

Dev Cell 2006
Participants
Participates
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Authored
Reviewed
Created
Cite Us!