Reactome | Dmel\CG2258 [cytosol]

Dmel\CG2258 [cytosol]

Stable Identifier

R-DME-2197671

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

NCKIPSD, Q9W3K6

Locations in the PathwayBrowser

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Immune System (Drosophila melanogaster)

- Innate Immune System (Drosophila melanogaster)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Drosophila melanogaster)
    - Regulation of actin dynamics for phagocytic cup formation (Drosophila melanogaster)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)
        
        Mother filament:branching complex [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
        
        SH3 domain proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG2258 [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
        
        SH3 domain proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG2258 [cytosol] (Drosophila melanogaster)
      - Detachment of WASP/WAVE (Drosophila melanogaster)
        
        Mother filament:branching complex [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
        
        SH3 domain proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG2258 [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
        
        SH3 domain proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG2258 [cytosol] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
  - Signaling by Rho GTPases (Drosophila melanogaster)
    - RHO GTPase Effectors (Drosophila melanogaster)
      - RHO GTPases Activate WASPs and WAVEs (Drosophila melanogaster)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)
        
        Mother filament:branching complex [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
        
        SH3 domain proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG2258 [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
        
        SH3 domain proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG2258 [cytosol] (Drosophila melanogaster)
        
        Detachment of WASP/WAVE (Drosophila melanogaster)
        
        Mother filament:branching complex [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
        
        SH3 domain proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG2258 [cytosol] (Drosophila melanogaster)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
        
        SH3 domain proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG2258 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W3K6

Gene Names

Dmel\CG2258

Reference Genes

BioGPS Gene:31729 Dmel\CG2258

ENSEMBL:FBgn0029997

FlyBase:FBgn0029997

KEGG:dme:Dmel_CG2258 Dmel\CG2258

Monarch:31729 Dmel\CG2258

NCBI Gene:31729 Dmel\CG2258

UCSC:Q9W3K6 Dmel\CG2258

Reference Transcript

Other Identifiers

154749_at

1625362_at

1629104_at

31729

GO:0005515

GO:0006897

GO:0008092

GO:0016192

GO:0017022

GO:0071933

Participates

as a member of

SH3 domain proteins [cytosol] (Drosophila melanogaster)

Inferred From

NCKIPSD [cytosol] (Homo sapiens)

Cross References

ENSEMBL

FBtr0071110, FBgn0029997, FBtr0340140, FBpp0071064, FBpp0309126, FBpp0071066, FBpp0071065, FBtr0071109, FBtr0071111

FlyBase

FBgn0029997

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