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Su(var)2-10 [nucleoplasm]
Stable Identifier
R-DME-2993789
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
PIAS4, A1Z7P5
Locations in the PathwayBrowser
Expand all
DNA Repair (Drosophila melanogaster)
DNA Double-Strand Break Repair (Drosophila melanogaster)
DNA Double Strand Break Response (Drosophila melanogaster)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Drosophila melanogaster)
ATM phosphorylates HERC2 (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
HERC2 and PIAS4 are recruited to DNA DSBs (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
RNF8 and RNF168 ubiquitinate H2AFX (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
RNF8 and RNF168 ubiquitinate KDM4A,B (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Metabolism of steroids (Drosophila melanogaster)
Vitamin D (calciferol) metabolism (Drosophila melanogaster)
PIAS4 SUMOylates VDR with SUMO2 (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
SUMOylation (Drosophila melanogaster)
SUMO E3 ligases SUMOylate target proteins (Drosophila melanogaster)
SUMOylation of DNA damage response and repair proteins (Drosophila melanogaster)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
SUMOylation of DNA replication proteins (Drosophila melanogaster)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
SUMOylation of intracellular receptors (Drosophila melanogaster)
PIAS4 SUMOylates VDR with SUMO2 (Drosophila melanogaster)
Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:A1Z7P5
Gene Names
Su(var)2-10
Reference Genes
BioGPS Gene:35927 Su(var)2-10
ENSEMBL:FBgn0003612
Flybase:FBgn0003612
Monarch:35927 Su(var)2-10
NCBI Gene:35927 Su(var)2-10
UCSC:A1Z7P5 Su(var)2-10
Reference Transcript
RefSeq:NM_165645.2 Su(var)2-10
Other Identifiers
1632783_a_at
35927
GO:0000724
GO:0000781
GO:0002376
GO:0003712
GO:0003824
GO:0005634
GO:0005652
GO:0005654
GO:0005694
GO:0005737
GO:0006281
GO:0006310
GO:0006351
GO:0006355
GO:0006357
GO:0007446
GO:0008270
GO:0016740
GO:0016925
GO:0023052
GO:0030261
GO:0036211
GO:0043226
GO:0045089
GO:0045880
GO:0046426
GO:0046872
GO:0048749
GO:0048856
GO:0050829
GO:0051276
GO:0061060
GO:0061665
GO:0097677
GO:0098542
GO:0110165
GO:0140096
GO:0140110
GO:1904677
Participates
as a component of
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
as an input of
HERC2 and PIAS4 are recruited to DNA DSBs (Drosophila melanogaster)
Other forms of this molecule
Su(var)2-10 [nucleoplasm]
Su(var)2-10 [nucleoplasm]
Su(var)2-10 [nucleoplasm]
Inferred From
PIAS4 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_724749.1
Flybase
FBgn0003612
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