Reactome | Dmel\CG32568 [cytosol]

Dmel\CG32568 [cytosol]

Stable Identifier

R-DME-3008954-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

PPP2R5C, Q9VXB7

Locations in the PathwayBrowser

Expand all

Immune System (Drosophila melanogaster)

- Adaptive Immune System (Drosophila melanogaster)
  - Costimulation by the CD28 family (Drosophila melanogaster)
    - CTLA4 inhibitory signaling (Drosophila melanogaster)
      - Dephosphorylation of AKT by PP2A (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Intracellular signaling by second messengers (Drosophila melanogaster)
  - PIP3 activates AKT signaling (Drosophila melanogaster)
    - Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
        
        AKT1 dephosphorylation by PP2A-B56-beta,gamma (Drosophila melanogaster)
        
        PP2A-B56-beta,gamma [cytosol] (Drosophila melanogaster)
        
        PPP2R5B,PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
        
        Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
        
        p-Y307-PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
- MAPK family signaling cascades (Drosophila melanogaster)
  - MAPK1/MAPK3 signaling (Drosophila melanogaster)
    - RAF/MAP kinase cascade (Drosophila melanogaster)
      - Negative regulation of MAPK pathway (Drosophila melanogaster)
        
        PP2A dephosphorylates RAF1 (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
      - RAF activation (Drosophila melanogaster)
        
        PP2A dephosphorylates KSR1 (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
        
        PP2A dephosphorylates inactive RAFs (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
- Signaling by WNT (Drosophila melanogaster)
  - Degradation of beta-catenin by the destruction complex (Drosophila melanogaster)
    - AXIN is phosphorylated in the destruction complex (Drosophila melanogaster)
      - AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
      - p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
    - Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Drosophila melanogaster)
      - RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Drosophila melanogaster)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
    - Association of beta-catenin with the destruction complex (Drosophila melanogaster)
      - CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
      - p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
    - Beta-catenin phosphorylation cascade (Drosophila melanogaster)
      - Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Drosophila melanogaster)
        
        CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
        
        p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
      - Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Drosophila melanogaster)
        
        p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
        
        p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
      - Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Drosophila melanogaster)
        
        p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
        
        p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
      - Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Drosophila melanogaster)
        
        p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
        
        p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
    - Degradation of ubiquitinated beta catenin by the proteasome (Drosophila melanogaster)
      - p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
      - ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Drosophila melanogaster)
        
        RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Drosophila melanogaster)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
    - Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Drosophila melanogaster)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
    - Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Drosophila melanogaster)
      - RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Drosophila melanogaster)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
      - ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Drosophila melanogaster)
        
        RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Drosophila melanogaster)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
    - Phosphorylation of APC component of the destruction complex (Drosophila melanogaster)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)
      - p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
        
        PP2A [cytosol] (Drosophila melanogaster)
        
        PP2A regulatory subunit B56 [cytosol] (Drosophila melanogaster)
        
        Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)
        
        Dmel\CG32568 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VXB7

Gene Names

Dmel\CG32568

Reference Genes

BioGPS Gene:32659 Dmel\CG32568

ENSEMBL:FBgn0052568

Flybase:FBgn0052568

KEGG Gene (Drosophila melanogaster):Dmel_CG32568 Dmel\CG32568

Monarch:32659 Dmel\CG32568

NCBI Gene:32659 Dmel\CG32568

UCSC:Q9VXB7 Dmel\CG32568

Reference Transcript

Other Identifiers

1634079_at

32659

GO:0000159

GO:0005634

GO:0005829

GO:0006470

GO:0007165

GO:0019888

GO:0023052

GO:0036211

GO:0043226

GO:0072542

GO:0098772

Participates

as a member of

Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)

Other forms of this molecule

Dmel\CG32568 [nucleoplasm]

Inferred From

PPP2R5C [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_728019.3, NP_001285351.1

Flybase

FBgn0052568

Cite Us!