DGO binds to DSH

Stable Identifier
R-DME-350436
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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DGO binds to DSH
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Diego (DGO) binding to Dishevelled (DSH) enhances Frizzled (FZ) PCP signalling. DGO, like FZ is required in R3/Distal cell fate. DGO binds to PDZ domain of DSH. DGO binding to DSH protects it from (Prickle) PK binding and its antagonistic effects. DGO could help promote DSH activation via stimulation of its phosphorylation.
Literature References
PubMed ID Title Journal Year
15937478 Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding

Burnett, M, Reynolds-Kenneally, J, Das, G, Jenny, A, Mlodzik, M

Nat Cell Biol 2005
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Authored
Williams, MG  (2008-05-20)
Reviewed
Axelrod, JD  (2009-11-19)
Created
Williams, MG  (2008-05-19)
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