Reactome | Vinc [cytosol]

Vinc [cytosol]

Stable Identifier

R-DME-350753

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

VCL, O46037

Locations in the PathwayBrowser

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Signal Transduction (Drosophila melanogaster)

- MAPK family signaling cascades (Drosophila melanogaster)
  - MAPK1/MAPK3 signaling (Drosophila melanogaster)
    - RAF/MAP kinase cascade (Drosophila melanogaster)
      - MAP2K and MAPK activation (Drosophila melanogaster)
        
        Dissociation of RAS:RAF complex (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
        
        RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
        
        Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
        
        Vinc [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:O46037

Gene Names

Vinc

Reference Genes

BioGPS Gene:31201 Vinc

ENSEMBL:FBgn0004397

Flybase:FBgn0004397

KEGG Gene (Drosophila melanogaster):Dmel_CG3299 Vinc

Monarch:31201 Vinc

NCBI Gene:31201 Vinc

Reference Transcript

Other Identifiers

143459_at

1631535_at

31201

GO:0003674

GO:0003779

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005856

GO:0005886

GO:0005912

GO:0005925

GO:0007155

GO:0008092

GO:0008150

GO:0015629

GO:0016020

GO:0030054

GO:0043226

GO:0051015

GO:0098592

Participates

as a member of

Platelet releasate cytosolic proteins [cytosol] (Drosophila melanogaster)

as a component of

Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)

Other forms of this molecule

Vinc [secretory granule lumen]

Vinc [specific granule lumen]

Vinc [extracellular region]

Vinc [ficolin-1-rich granule lumen]

Inferred From

VCL [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001284813.1, NP_001284814.1, NP_476820.1

Flybase

FBgn0004397

PRO

O46037

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