AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene

Stable Identifier
Reaction [binding]
Drosophila melanogaster
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

When the JNK pathway is activated, the AP-1 transcription factor, a complex Jun-related antigen (JRA) and Kayak (KAY), forms a complex with the HMG protein, dorsal switch protein (DSP1) and STAT92E transcription factor (involved in the JAK/STAT pathway). This 'repressosome complex' and phosphorylated Relish (REL-68) are mutually exclusive in binding to this gene and so phosphorylated REL-68 is displaced from its target gene.

Literature References
PubMed ID Title Journal Year
17803358 Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila

Kim, LK, Choi, UY, Cho, HS, Lee, JS, Lee, WB, Kim, J, Jeong, K, Shim, J, Kim-Ha, J, Kim, YJ

PLoS Biol 2007
15640802 Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules

Kim, T, Yoon, J, Cho, H, Lee, WB, Kim, J, Song, YH, Kim, SN, Yoon, JH, Kim-Ha, J, Kim, YJ

Nat Immunol 2005
Cite Us!