Reactome | CHD4 [nucleoplasm]

CHD4 [nucleoplasm]

Stable Identifier

R-DME-3702078

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

O16102

Locations in the PathwayBrowser

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Chromatin organization (Drosophila melanogaster)

- Chromatin modifying enzymes (Drosophila melanogaster)
  - HDACs deacetylate histones (Drosophila melanogaster)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Drosophila melanogaster)
      - HDAC1:2-containing complex [nucleoplasm] (Drosophila melanogaster)
        
        NuRD complex [nucleoplasm] (Drosophila melanogaster)
        
        Mi-2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHD4 [nucleoplasm] (Drosophila melanogaster)
        
        CHD4 [nucleoplasm] (Drosophila melanogaster)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Drosophila melanogaster)
        
        HDAC1:2-containing complex [nucleoplasm] (Drosophila melanogaster)
        
        NuRD complex [nucleoplasm] (Drosophila melanogaster)
        
        Mi-2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHD4 [nucleoplasm] (Drosophila melanogaster)
        
        CHD4 [nucleoplasm] (Drosophila melanogaster)
    - HDAC1:2-containing complex deacetylate histones (Drosophila melanogaster)
      - HDAC1:2-containing complex [nucleoplasm] (Drosophila melanogaster)
        
        NuRD complex [nucleoplasm] (Drosophila melanogaster)
        
        Mi-2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHD4 [nucleoplasm] (Drosophila melanogaster)
        
        CHD4 [nucleoplasm] (Drosophila melanogaster)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Drosophila melanogaster)
        
        HDAC1:2-containing complex [nucleoplasm] (Drosophila melanogaster)
        
        NuRD complex [nucleoplasm] (Drosophila melanogaster)
        
        Mi-2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHD4 [nucleoplasm] (Drosophila melanogaster)
        
        CHD4 [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional Regulation by TP53 (Drosophila melanogaster)
      - Regulation of TP53 Activity (Drosophila melanogaster)
        
        Regulation of TP53 Activity through Acetylation (Drosophila melanogaster)
        
        MTA2-NuRD complex deacetylates TP53 (Drosophila melanogaster)
        
        MTA2-NuRD complex [nucleoplasm] (Drosophila melanogaster)
        
        Mi-2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHD4 [nucleoplasm] (Drosophila melanogaster)
        
        CHD4 [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Intracellular signaling by second messengers (Drosophila melanogaster)
  - PIP3 activates AKT signaling (Drosophila melanogaster)
    - PTEN Regulation (Drosophila melanogaster)
      - Regulation of PTEN gene transcription (Drosophila melanogaster)
        
        SALL4 recruits NuRD to PTEN gene (Drosophila melanogaster)
        
        NuRD complex [nucleoplasm] (Drosophila melanogaster)
        
        Mi-2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHD4 [nucleoplasm] (Drosophila melanogaster)
        
        CHD4 [nucleoplasm] (Drosophila melanogaster)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Drosophila melanogaster)
        
        SALL4:NuRD [nucleoplasm] (Drosophila melanogaster)
        
        NuRD complex [nucleoplasm] (Drosophila melanogaster)
        
        Mi-2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHD4 [nucleoplasm] (Drosophila melanogaster)
        
        CHD4 [nucleoplasm] (Drosophila melanogaster)
- Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
  - Signaling by NTRKs (Drosophila melanogaster)
    - Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
      - Nuclear Events (kinase and transcription factor activation) (Drosophila melanogaster)
        
        NGF-stimulated transcription (Drosophila melanogaster)
        
        NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Drosophila melanogaster)
        
        Homologues of CHD4 [nucleoplasm] (Drosophila melanogaster)
        
        CHD4 [nucleoplasm] (Drosophila melanogaster)
        
        RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHD4 [nucleoplasm] (Drosophila melanogaster)
        
        CHD4 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:O16102

Reference Genes

BioGPS Gene:40111

ENSEMBL:FBgn0023395

Flybase:FBgn0023395

KEGG Gene (Drosophila melanogaster):Dmel_CG9594

Monarch:40111

NCBI Gene:40111

UCSC:O16102

Reference Transcript

RefSeq:NM_140854.3

Other Identifiers

143981_at

1630786_at

40111

GO:0000122

GO:0000166

GO:0000785

GO:0000791

GO:0003677

GO:0003682

GO:0003824

GO:0004386

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0016581

GO:0016787

GO:0016887

GO:0034728

GO:0042393

GO:0043226

GO:0046872

GO:0140097

GO:0140657

GO:0140658

Participates

as a member of

Homologues of CHD4 [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

CHD3 [nucleoplasm]

Inferred From

CHD4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_649111.1

Flybase

FBgn0023395

PRO

O16102

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