Reactome | SIAH2 [cytosol]

SIAH2 [cytosol]

Stable Identifier

R-DME-374566

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

P21461

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P21461

Reference Genes

BioGPS Gene:39884

ENSEMBL:FBgn0003410

Flybase:FBgn0003410

KEGG Gene (Drosophila melanogaster):Dmel_CG9949

Monarch:39884

NCBI Gene:39884

Reference Transcript

Other Identifiers

153438_at

1632100_s_at

39884

GO:0000151

GO:0004842

GO:0005515

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006511

GO:0007275

GO:0007423

GO:0007465

GO:0007601

GO:0008270

GO:0010498

GO:0016567

GO:0016740

GO:0023052

GO:0030154

GO:0030163

GO:0031624

GO:0032436

GO:0032991

GO:0035883

GO:0036211

GO:0042025

GO:0042802

GO:0043161

GO:0043226

GO:0045500

GO:0045676

GO:0046872

GO:0048856

GO:0050877

GO:0050896

GO:0061630

GO:0140096

Participates

as an input of

USP13 binds SIAH2 (Drosophila melanogaster)

as a component of

SIAH2:USP13 [cytosol] (Drosophila melanogaster)

as a member of

E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)

Other forms of this molecule

SIAH1 [cytosol]

Inferred From

SIAH2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_476725.1, NP_730206.1, NP_001287089.1

Flybase

FBgn0003410

PRO

P21461

Interactors (80)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q27934 PHYL			0.853	12
UniProt:Q9W3H5 Q9W3H5			0.742	5
UniProt:P42282 TTKA			0.681	4
UniProt:A1Z8K2 A1Z8K2			0.666	4
UniProt:Q9V3G9 Q9V3G9			0.621	3
UniProt:Q9W483 Q9W483			0.621	3
UniProt:Q9VFT4 Q9VFT4			0.621	3
UniProt:P21461	2	SIAH2 [cytosol] (R-DME-374566) SIAH1 [cytosol] (R-DME-374563)	0.573	2
UniProt:Q95RJ9	2	ebi [nucleoplasm] (R-DME-351643) ebi [nucleoplasm] (R-DME-351644)	0.499	3
UniProt:Q9I7W2	4	Dmel\CG12106 [nucleoplasm] (R-DME-8955108) Dmel\CG12106 [cytosol] (R-DME-8955113) Dmel\CG12106 [extracellular region] (R-DME-6806501) Dmel\CG12106 [ficolin-1-rich granule lumen] (R-DME-6801405)	0.488	2
UniProt:Q9VA79	1	UIP5 [cytosol] (R-DME-976034)	0.488	2
UniProt:Q9VPZ1 Q9VPZ1			0.488	2
UniProt:Q24318-2 DP			0.488	2
UniProt:P35128 ben	6	BEN [cytosol] (R-DME-205841) ben [nucleoplasm] (R-DME-8943013) ben [cytosol] (R-DME-8864210) ben [nucleoplasm] (R-DME-6790511) ben [nucleoplasm] (R-DME-5682541) ben [cytosol] (R-DME-206072)	0.488	2
UniProt:P22293	1	su(sable) [nucleoplasm] (R-DME-6807406)	0.488	2
UniProt:Q8T390	5	EndoA [Golgi membrane] (R-DME-351189) EndoA [plasma membrane] (R-DME-177495) EndoA [cytosol] (R-DME-182958) EndoA [cytosol] (R-DME-8867734) EndoA [cytosol] (R-DME-8867732)	0.488	2
UniProt:Q9VIK7 Q9VIK7			0.488	2
UniProt:Q9VWS0 Q9VWS0			0.488	2
UniProt:Q8IHH3 Q8IHH3			0.488	2
UniProt:Q9VNE1	1	PolZ2 [nucleoplasm] (R-DME-59092)	0.488	2
UniProt:Q29R02 Q29R02			0.488	2
UniProt:Q9VRY7 Q9VRY7			0.488	2
UniProt:Q9VB25	1	KIF16B [cytosol] (R-DME-8849362)	0.488	2
UniProt:P05084 HUNB			0.488	2
UniProt:Q9VKU4 Q9VKU4			0.488	2
UniProt:O62602	6	lic [cytosol] (R-DME-167998) lic [cytosol] (R-DME-168051) phospho-lic [cytosol] (R-DME-206255) phospho-lic [cytosol] (R-DME-167955) phospho-lic [nucleoplasm] (R-DME-450258) phospho-lic [nucleoplasm] (R-DME-450229)	0.488	2
UniProt:Q8INY6 Q8INY6			0.488	2
UniProt:Q8INY5 Q8INY5			0.488	2
UniProt:Q9VZJ1 Q9VZJ1			0.488	2
UniProt:Q9V3M9 Q9V3M9			0.488	2
UniProt:Q4V6Y7 Q4V6Y7			0.488	2
UniProt:Q9VRN5	1	LIN28A [cytosol] (R-DME-500391)	0.488	2
UniProt:Q9W2P8 Q9W2P8			0.488	2
UniProt:Q9VLF2 Q9VLF2			0.488	2
UniProt:C6SV46 C6SV46			0.488	2
UniProt:Q9VW77 Q9VW77			0.488	2
UniProt:M9PHB8 M9PHB8			0.488	2
UniProt:Q8MKK6 Q8MKK6			0.488	2
UniProt:Q9VPV6 Q9VPV6			0.488	2
UniProt:Q961D1	1	CycK [nucleoplasm] (R-DME-6796619)	0.488	2
UniProt:Q7K2G1-2 RPN13			0.488	2
UniProt:Q9W2A3 Q9W2A3			0.488	2
UniProt:A0A4D6K416 A0A4D6K416			0.488	2
UniProt:Q9VL73 Q9VL73			0.488	2
UniProt:Q05856	3	SmB [nucleoplasm] (R-DME-192213) SmB [nucleoplasm] (R-DME-71896) SmB [cytosol] (R-DME-191798)	0.488	2
UniProt:Q0IGU0 Q0IGU0			0.488	2
UniProt:Q9VDX4 Q9VDX4			0.488	2
UniProt:Q9W0A2 Q9W0A2			0.488	2
UniProt:Q058Z8 Q058Z8			0.488	2
UniProt:P82295 PROML			0.488	2
UniProt:P23792 DISC			0.488	2
UniProt:Q9VQU9 BOWEL			0.488	2
UniProt:Q9VIE6	1	Mcm10 [nucleoplasm] (R-DME-68403)	0.488	2
UniProt:Q9Y106 MB21L			0.488	2
UniProt:P23757 POXM			0.488	2
UniProt:Q9VJS5 Q9VJS5			0.488	2
UniProt:Q5BIB4 Q5BIB4			0.488	2
UniProt:Q9W481	1	Dmel\CG15771 [cytosol] (R-DME-4085391)	0.488	2
UniProt:C6SV53 C6SV53			0.488	2
UniProt:D5A7J7 D5A7J7			0.488	2
UniProt:Q9VBQ3	1	Dmel\CG5111 [cytosol] (R-DME-8956129)	0.488	2
UniProt:Q9VDP8	1	mdlc [nucleoplasm] (R-DME-9769563)	0.488	2
UniProt:Q9VRL1 Uev1A	4	UEV1A [cytosol] (R-DME-206024) Uev1A [cytosol] (R-DME-947624) Uev1A [nucleoplasm] (R-DME-5682543) Uev1A [cytosol] (R-DME-205753)	0.488	2
UniProt:P52486	2	Ubc4 [cytosol] (R-DME-8864200) Ubc4 [cytosol] (R-DME-934631)	0.488	2
UniProt:P52487	2	Ubc84D [nucleoplasm] (R-DME-5653666) Ubc84D [cytosol] (R-DME-936014)	0.488	2
UniProt:Q9XZ57 Q9XZ57			0.488	2
UniProt:Q01070 ESMC			0.488	2
UniProt:P23023-2 DSX			0.488	2
UniProt:Q9W0B3 Q9W0B3			0.488	2
UniProt:Q058W3 Q058W3			0.488	2
UniProt:Q9GQQ0-3 SPIN			0.488	2
UniProt:Q29QK1 Q29QK1			0.488	2
UniProt:A1Z904 A1Z904			0.488	2
UniProt:Q9VWN5 MINY3			0.488	2
UniProt:Q9W4B3 Q9W4B3			0.488	2
UniProt:P17789 TTKB			0.488	2
UniProt:Q961J0 Q961J0			0.488	2
UniProt:P23758	1	Poxn [nucleoplasm] (R-DME-158583-2)	0.488	2
UniProt:P40417	8	MAPK1 [azurophil granule lumen] (R-DME-6799225) MAPK1 [extracellular region] (R-DME-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-DME-6800964) phospho-p-T185-MAPK1 [cytosol] (R-DME-9635773) MAPK1 [nucleoplasm] (R-DME-199960) MAPK1 [cytosol] (R-DME-59282) phospho-p-T185,Y187-MAPK1 [cytosol] (R-DME-109853) phospho-p-T185,Y187-MAPK1 [nucleoplasm] (R-DME-112354)	0.488	2
UniProt:Q8I942 Q8I942			0.488	2

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