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nej [nucleoplasm]
Stable Identifier
R-DME-381325
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
EP300, M9MS40
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to hypoxia (Drosophila melanogaster)
Regulation of gene expression by Hypoxia-inducible Factor (Drosophila melanogaster)
Formation of HIF:CBP:p300 complex at promoters (Drosophila melanogaster)
HIF:CBP:p300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Chromatin organization (Drosophila melanogaster)
Chromatin modifying enzymes (Drosophila melanogaster)
HATs acetylate histones (Drosophila melanogaster)
EP300 acetylates histone H2A, H2B, H3, H4 (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
FOXO-mediated transcription (Drosophila melanogaster)
Regulation of FOXO transcriptional activity by acetylation (Drosophila melanogaster)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Drosophila melanogaster)
KAT2B,(EP300) [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
Regulation of TP53 Activity (Drosophila melanogaster)
Regulation of TP53 Activity through Acetylation (Drosophila melanogaster)
BRD7 binds TP53 and EP300 (Drosophila melanogaster)
BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
BRD7 promotes EP300-mediated acetylation of TP53 (Drosophila melanogaster)
BRD7:Ac-K382,p-S15,S20-TP53:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
MTA2-NuRD complex deacetylates TP53 (Drosophila melanogaster)
BRD7:Ac-K382,p-S15,S20-TP53:EP300, KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (Drosophila melanogaster)
BRD7:Ac-K382,p-S15,S20-TP53:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53, BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Drosophila melanogaster)
BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
PI5P Regulates TP53 Acetylation (Drosophila melanogaster)
ING2 recruits EP300 to TP53 (Drosophila melanogaster)
ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
ING2-bound EP300 acetylates TP53 (Drosophila melanogaster)
ING2:EP300:Ac-K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Transcriptional regulation by RUNX1 (Drosophila melanogaster)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Drosophila melanogaster)
HIPK2 phosphorylates RUNX1 and EP300 (Drosophila melanogaster)
RUNX1:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
RUNX1:CBFB binds EP300 (Drosophila melanogaster)
RUNX1:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Drosophila melanogaster)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Drosophila melanogaster)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Transcriptional regulation by RUNX3 (Drosophila melanogaster)
RUNX3 regulates p14-ARF (Drosophila melanogaster)
Acetylated RUNX3 binds to BRD2 (Drosophila melanogaster)
Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Drosophila melanogaster)
Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
CCND1 binds RUNX3 and displaces EP300 (Drosophila melanogaster)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Drosophila melanogaster)
Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
EP300 acetylates RUNX3 (Drosophila melanogaster)
Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
RUNX3:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
RUNX3 binds EP300 (Drosophila melanogaster)
RUNX3:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Regulation of RUNX3 expression and activity (Drosophila melanogaster)
SMURFs ubiquitinate RUNX3 (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
Metalloprotease DUBs (Drosophila melanogaster)
MYSM1 deubiquitinates Histone H2A (Drosophila melanogaster)
MYSM1:EP300:KAT2B:Histone H2A [nucleoplasm] (Drosophila melanogaster)
MYSM1:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
MYSM1:EP300:KAT2B:Ub-histone H2A [nucleoplasm] (Drosophila melanogaster)
MYSM1:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Estrogen-dependent gene expression (Drosophila melanogaster)
Binding of AP1 transcriptional activator complexes to CCND1 promoter (Drosophila melanogaster)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
EP300 is recruited to MYC and BCL2 genes (Drosophila melanogaster)
MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
ESR1:ESTG and EP300 are recruited to TFF3 promoter (Drosophila melanogaster)
TFF3 gene:FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
HATs and coactivators are recruited to the CTSD gene (Drosophila melanogaster)
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Histone acetyltransferases are recruited to the TFF1 gene (Drosophila melanogaster)
ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Drosophila melanogaster)
histone acetyltransferases [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
histone acetyltransferases [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
NCOA1 recruits EP300 to TGFA promoter (Drosophila melanogaster)
ESR1:estrogen:TFGA gene:NCOA1:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Drosophila melanogaster)
ESR1:estrogen:ERE:NCOA3:EP300 [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
NR1H2 and NR1H3-mediated signaling (Drosophila melanogaster)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Drosophila melanogaster)
NCOA1 recruits EP300 to the ABCA1 promoter (Drosophila melanogaster)
EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ALK (Drosophila melanogaster)
STAT3 nuclear events downstream of ALK signaling (Drosophila melanogaster)
p-Y705,S727 STAT3 is acetylated (Drosophila melanogaster)
nej [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:M9MS40
Gene Names
nej
Reference Genes
BioGPS Gene:43856 nej
ENSEMBL:FBgn0261617
Flybase:FBgn0261617
KEGG Gene (Drosophila melanogaster):Dmel_CG15319 nej
Monarch:43856 nej
NCBI Gene:43856 nej
Reference Transcript
RefSeq:NM_001201646.2 nej
Other Identifiers
144765_at
154642_at
1622925_at
1637135_at
43856
GO:0000076
GO:0000123
GO:0000278
GO:0001745
GO:0003677
GO:0003712
GO:0003713
GO:0003824
GO:0004402
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005700
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0007088
GO:0007163
GO:0007269
GO:0007416
GO:0007464
GO:0008134
GO:0008270
GO:0008347
GO:0016573
GO:0016740
GO:0016746
GO:0022414
GO:0023052
GO:0030154
GO:0030707
GO:0031490
GO:0032922
GO:0032991
GO:0034330
GO:0035097
GO:0036211
GO:0040040
GO:0043226
GO:0043229
GO:0043993
GO:0044017
GO:0045466
GO:0045475
GO:0045880
GO:0045944
GO:0046872
GO:0048749
GO:0048856
GO:0048870
GO:0050896
GO:0061629
GO:0090090
GO:0090263
GO:0098793
GO:0140014
GO:0140096
GO:0140110
GO:0140297
GO:1990226
Participates
as an input of
NCOA1 recruits EP300 to the ABCA1 promoter (Drosophila melanogaster)
HATs and coactivators are recruited to the CTSD gene (Drosophila melanogaster)
NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Drosophila melanogaster)
ESR1:ESTG and EP300 are recruited to TFF3 promoter (Drosophila melanogaster)
NCOA1 recruits EP300 to TGFA promoter (Drosophila melanogaster)
EP300 is recruited to MYC and BCL2 genes (Drosophila melanogaster)
RUNX1:CBFB binds EP300 (Drosophila melanogaster)
RUNX3 binds EP300 (Drosophila melanogaster)
BRD7 binds TP53 and EP300 (Drosophila melanogaster)
ING2 recruits EP300 to TP53 (Drosophila melanogaster)
Formation of HIF:CBP:p300 complex at promoters (Drosophila melanogaster)
Binding of AP1 transcriptional activator complexes to CCND1 promoter (Drosophila melanogaster)
as a component of
EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Drosophila melanogaster)
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Drosophila melanogaster)
ESR1:estrogen:ERE:NCOA3:EP300 [nucleoplasm] (Drosophila melanogaster)
TFF3 gene:FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm] (Drosophila melanogaster)
ESR1:estrogen:TFGA gene:NCOA1:EP300 [nucleoplasm] (Drosophila melanogaster)
MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300 [nucleoplasm] (Drosophila melanogaster)
MYSM1:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
RUNX1:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Drosophila melanogaster)
RUNX3:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
BRD7:Ac-K382,p-S15,S20-TP53:EP300 [nucleoplasm] (Drosophila melanogaster)
BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Drosophila melanogaster)
ING2:EP300:Ac-K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Drosophila melanogaster)
ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] (Drosophila melanogaster)
HIF:CBP:p300 [nucleoplasm] (Drosophila melanogaster)
NOTCH1 Coactivator Complex [nucleoplasm] (Drosophila melanogaster)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Drosophila melanogaster)
as a member of
histone acetyltransferases [nucleoplasm] (Drosophila melanogaster)
as a candidate of
KAT2B,(EP300) [nucleoplasm] (Drosophila melanogaster)
as an output of
CCND1 binds RUNX3 and displaces EP300 (Drosophila melanogaster)
This entity regulates
Negatively
SMURFs ubiquitinate RUNX3
(Drosophila melanogaster)
Other forms of this molecule
phospho-nej [nucleoplasm]
nej [nucleoplasm]
Inferred From
EP300 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001188575.1
Flybase
FBgn0261617
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