HPO dimer binds to RASSF

Stable Identifier
R-DME-390059
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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HPO dimer binds to RASSF
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Ras association family member (RASSF) associates with inactive Hippo (HPO) kinase homodimer through their shared SARAH (Salvador/Rassf/Hippo) domains. It should be noted that Hippo (HPO) kinase domain also associates with scaffolding protein Salvador (SAV) through SARAH domains. However, RASSF fails to bind to SAV. HPO associated with RASSF shows barely detectable levels of phosphorylation. In this complex, HPO homodimer remains unphosphorylated and inactive. Thus, RASSF restricts HPO activity by competing with SAV for binding to HPO homodimer.
Literature References
PubMed ID Title Journal Year
17174922 The Drosophila RASSF homolog antagonizes the hippo pathway

Tapon, N, Huelsmann, S, Polesello, C, Brown, NH

Curr Biol 2006
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Authored
Williams, MG  (2009-01-23)
Reviewed
Irvine, KD  (2009-11-25)
Created
Williams, MG  (2009-01-23)
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