14-3-3 dimer binds to phosphorylated YKI

Stable Identifier
R-DME-390078
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
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The phosphorylated transcription factor Yorkie (YKI) associates with either one of the two 14-3-3 dimer isoforms (14-3-3epsilon or 14-3-3zeta). This effectively anchors YKI in the cytosol and prevents it entering the nucleus to activate its target genes.

Literature References
PubMed ID Title Journal Year
17889654 Elucidation of a universal size-control mechanism in Drosophila and mammals

Dong, J, Feldmann, G, Huang, J, Wu, S, Zhang, N, Comerford, SA, Gayyed, MF, Anders, RA, Maitra, A, Pan, D

Cell 2007
18256197 In vivo regulation of Yorkie phosphorylation and localization

Oh, H, Irvine, KD

Development 2008
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