WTS binds to SAV

Stable Identifier
R-DME-390087
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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WTS binds to SAV
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The serine/threonine kinase, Warts (WTS), binds to the WW domain of the scaffolding protein Salvador (SAV). Hippo (HPO) kinase homodimer and WTS bind to different portions of SAV and the three proteins form a ternary complex.
Literature References
PubMed ID Title Journal Year
12202036 salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

Bell, DW, Tapon, N, Schiripo, TA, Harvey, KF, Wahrer, DC, Haber, DA, Hariharan, IK

Cell 2002
12941274 The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

Harvey, KF, Pfleger, CM, Hariharan, IK

Cell 2003
14502295 The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila

Tapon, N, Léopold, P, Pantalacci, S

Nat Cell Biol 2003
12941273 hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

Wu, S, Pan, D, Dong, J, Huang, J

Cell 2003
Participants
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Output
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Authored
Williams, MG  (2009-01-23)
Reviewed
Irvine, KD  (2009-11-25)
Created
Williams, MG  (2009-01-23)
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