Phospho FT reduces D accumulation at the plasma membrane

Stable Identifier
R-DME-390116
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phospho FT reduces D accumulation at the plasma membrane
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There are observations that Fat (FT), Dachsous (DS), and Four-jointed (FJ) modulate the subcellular localisation of Dachs (D). In the absence of FT, D accumulates at the plasma membrane. These suggest a simple model whereby signalling through FT regulates the stability of the serine/threonine kinase, Warts (WTS), by reducing protein levels of D at the plasma membrane so it fails to interact with WTS.
Literature References
PubMed ID Title Journal Year
16980976 Delineation of a Fat tumor suppressor pathway

Fehon, R, Irvine, KD, Maitra, S, Rauskolb, C, Feng, Y, Cho, E

Nat Genet 2006
16735478 Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila

Minihan, G, Irvine, KD, Hu, WL, Rauskolb, C, Mao, Y, Hayter, H, Katz, FN, Cho, E

Development 2006
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Authored
Williams, MG  (2009-01-23)
Reviewed
Irvine, KD  (2009-11-25)
Created
Williams, MG  (2009-01-23)
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