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Vhl [cytosol]
Stable Identifier
R-DME-391423
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
VHL, Q9V3C1
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)
VBC complex (with or without LIMD1) [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
26S proteasome degrades HIFalpha (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
CUL2-box protein [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
NEDD8-CRL2 E3 ligase complex [cytosol] (Drosophila melanogaster)
CUL2-box protein [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
CUL2-box protein [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
CUL2-box protein [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
CUL2-box protein [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
NEDD8-CRL2 E3 ligase complex [cytosol] (Drosophila melanogaster)
CUL2-box protein [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
CUL2-box protein [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
CUL2-box protein [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
RHOBTB3 ATPase cycle (Drosophila melanogaster)
RHOBTB3 binds interacting proteins at trans-Golgi network (Drosophila melanogaster)
RHOBTB3 interacting proteins [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Drosophila melanogaster)
RHOBTB3 interacting proteins [cytosol] (Drosophila melanogaster)
Vhl [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9V3C1
Gene Names
Vhl
Reference Genes
BioGPS Gene:53433 Vhl
ENSEMBL:FBgn0041174
Flybase:FBgn0041174
KEGG Gene (Drosophila melanogaster):Dmel_CG13221 Vhl
Monarch:53433 Vhl
NCBI Gene:53433 Vhl
Reference Transcript
RefSeq:NM_080247.3 Vhl
RefSeq:NM_001273956.1 Vhl
Other Identifiers
147004_at
1636856_at
53433
GO:0000278
GO:0001525
GO:0005515
GO:0005634
GO:0006611
GO:0006886
GO:0006913
GO:0007010
GO:0007026
GO:0007059
GO:0007098
GO:0007163
GO:0007424
GO:0007427
GO:0016334
GO:0016567
GO:0030154
GO:0030891
GO:0035149
GO:0036211
GO:0043226
GO:0048856
GO:0048870
GO:0060438
GO:0090307
GO:0140014
GO:1900037
Participates
as a member of
RHOBTB3 interacting proteins [cytosol] (Drosophila melanogaster)
CUL2-box protein [cytosol] (Drosophila melanogaster)
as a component of
VBC complex [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Vhl [nucleoplasm]
Inferred From
VHL [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001260885.1
,
NP_524986.1
Flybase
FBgn0041174
PRO
Q9V3C1
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