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Cul2 [cytosol]
Stable Identifier
R-DME-416982
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
CUL2, Q9V9R2
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)
VBC complex (with or without LIMD1) [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul2 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9V9R2
Gene Names
Cul2
Reference Genes
BioGPS Gene:35420 Cul2
ENSEMBL:FBgn0032956
FlyBase:FBgn0032956
KEGG Gene (Drosophila melanogaster):Dmel_CG1512 Cul2
Monarch:35420 Cul2
NCBI Gene:35420 Cul2
UCSC:Q9V9R2 Cul2
Reference Transcript
RefSeq:NM_136273.3 Cul2
RefSeq:NM_165390.2 Cul2
Other Identifiers
154761_at
1637515_s_at
35420
GO:0006511
GO:0007281
GO:0007295
GO:0008582
GO:0016032
GO:0016567
GO:0019005
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030514
GO:0030674
GO:0031146
GO:0031461
GO:0031462
GO:0031625
GO:0032436
GO:0034330
GO:0036211
GO:0046426
GO:0048140
GO:0048471
GO:0048856
GO:0060090
Participates
as a component of
CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Cul2 [cytosol]
Cul2 [nucleoplasm]
Inferred From
CUL2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_724352.1
,
NP_610117.1
Flybase
FBgn0032956
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7JWD6
2
EloC [nucleoplasm]
(R-DME-112422)
EloC [cytosol]
(R-DME-180535)
0.547
2
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