Reactome | GRM2 [plasma membrane]

GRM2 [plasma membrane]

Stable Identifier

R-DME-420468

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

plasma membrane

Synonyms

P91685

Locations in the PathwayBrowser

Expand all

Signal Transduction (Drosophila melanogaster)

- Signaling by GPCR (Drosophila melanogaster)
  - GPCR downstream signalling (Drosophila melanogaster)
    - G alpha (i) signalling events (Drosophila melanogaster)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        GRM1-8:L-Glu [plasma membrane] (Drosophila melanogaster)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Drosophila melanogaster)
        
        GRM2 [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        GRM1-8:L-Glu [plasma membrane] (Drosophila melanogaster)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Drosophila melanogaster)
        
        GRM2 [plasma membrane] (Drosophila melanogaster)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        GRM1-8:L-Glu [plasma membrane] (Drosophila melanogaster)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Drosophila melanogaster)
        
        GRM2 [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        GRM1-8:L-Glu [plasma membrane] (Drosophila melanogaster)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Drosophila melanogaster)
        
        GRM2 [plasma membrane] (Drosophila melanogaster)
      - The Ligand:GPCR:Gi complex dissociates (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        GRM1-8:L-Glu [plasma membrane] (Drosophila melanogaster)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Drosophila melanogaster)
        
        GRM2 [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        GRM1-8:L-Glu [plasma membrane] (Drosophila melanogaster)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Drosophila melanogaster)
        
        GRM2 [plasma membrane] (Drosophila melanogaster)
  - GPCR ligand binding (Drosophila melanogaster)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Drosophila melanogaster)
      - Metabotropic glutamate receptors bind glutamate (Drosophila melanogaster)
        
        GRM1-8:L-Glu [plasma membrane] (Drosophila melanogaster)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Drosophila melanogaster)
        
        GRM2 [plasma membrane] (Drosophila melanogaster)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Drosophila melanogaster)
        
        GRM2 [plasma membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P91685

Reference Genes

BioGPS Gene:43838

ENSEMBL:FBgn0019985

Flybase:FBgn0019985

KEGG Gene (Drosophila melanogaster):Dmel_CG11144

Monarch:43838

NCBI Gene:43838

Reference Transcript

Other Identifiers

143909_at

1639492_at

43838

GO:0001640

GO:0001641

GO:0004930

GO:0005886

GO:0007154

GO:0007165

GO:0007186

GO:0007196

GO:0007216

GO:0007528

GO:0007612

GO:0007614

GO:0007616

GO:0008049

GO:0008066

GO:0008289

GO:0015485

GO:0016020

GO:0016595

GO:0022414

GO:0023052

GO:0034330

GO:0038038

GO:0045121

GO:0050877

GO:0051966

GO:0060089

GO:0072553

Participates

as a member of

GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Drosophila melanogaster)

Other forms of this molecule

GRM3 [plasma membrane]

Inferred From

GRM2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001259076.1, NP_524639.2

Flybase

FBgn0019985

PRO

P91685