Reactome | GABA-B-R1 [plasma membrane]

GABA-B-R1 [plasma membrane]

Stable Identifier

R-DME-420716

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

plasma membrane

Synonyms

GABBR1, Q9V3Q9

Locations in the PathwayBrowser

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Neuronal System (Drosophila melanogaster)

- Potassium Channels (Drosophila melanogaster)
  - Inwardly rectifying K+ channels (Drosophila melanogaster)
    - G protein gated Potassium channels (Drosophila melanogaster)
      - Activation of G protein gated Potassium channels (Drosophila melanogaster)
        
        Activation of GIRK/Kir3 Channels (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)
- Transmission across Chemical Synapses (Drosophila melanogaster)
  - Neurotransmitter receptors and postsynaptic signal transmission (Drosophila melanogaster)
    - GABA receptor activation (Drosophila melanogaster)
      - GABA B receptor activation (Drosophila melanogaster)
        
        Activation of GABAB receptors (Drosophila melanogaster)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Drosophila melanogaster)
        
        Activation of GIRK/Kir3 Channels (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)
        
        GABAB heterodimeric receptor binds GABA (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by GPCR (Drosophila melanogaster)
  - GPCR downstream signalling (Drosophila melanogaster)
    - G alpha (i) signalling events (Drosophila melanogaster)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)
  - GPCR ligand binding (Drosophila melanogaster)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Drosophila melanogaster)
      - GABAB heterodimeric receptor binds GABA (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Drosophila melanogaster)
        
        GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)
        
        GABA-B-R1 [plasma membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9V3Q9

Gene Names

GABA-B-R1

Reference Genes

BioGPS Gene:34878 GABA-B-R1

ENSEMBL:FBgn0260446

Flybase:FBgn0260446

KEGG Gene (Drosophila melanogaster):Dmel_CG15274 GABA-B-R1

Monarch:34878 GABA-B-R1

NCBI Gene:34878 GABA-B-R1

UCSC:Q9V3Q9 GABA-B-R1

Reference Transcript

Other Identifiers

144312_at

1630047_at

34878

GO:0003674

GO:0004888

GO:0004930

GO:0004965

GO:0005575

GO:0005886

GO:0005887

GO:0007154

GO:0007165

GO:0007186

GO:0007193

GO:0007214

GO:0007267

GO:0008150

GO:0016020

GO:0016021

GO:0023052

GO:0032991

GO:0038039

GO:0046982

GO:0050896

GO:0110165

Participates

as a component of

GABBR1:GABBR2 [plasma membrane] (Drosophila melanogaster)

Inferred From

GABBR1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_523569.3, NP_001246033.1

Flybase

FBgn0260446

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9VPP0	3	Ent1 [lysosomal membrane] (R-DME-727733) Ent1 [plasma membrane] (R-DME-54335) Ent1 [plasma membrane] (R-DME-54337)	0.488	2
UniProt:Q7KVA1	2	oxt [Golgi membrane] (R-DME-8863596) oxt [Golgi membrane] (R-DME-8863600)	0.488	2
UniProt:Q8MS59	1	wat [peroxisomal membrane] (R-DME-390430)	0.488	2
UniProt:Q9VL16	4	phospho-Dmel\CG5676 [mitochondrial outer membrane] (R-DME-8948140) phospho-Dmel\CG5676 [mitochondrial outer membrane] (R-DME-8934915) Dmel\CG5676 [mitochondrial outer membrane] (R-DME-8934922) phospho-Dmel\CG5676 [mitochondrial outer membrane] (R-DME-8934910)	0.488	2

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