Recruitment of Pak to Dock

Stable Identifier
R-DME-428527
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Recruitment of Pak to Dock
In Drosophila, Dock bound to Robo1 recruits Pak to specific sites at the growth cone membrane, where Pak, activated by Rac1, regulates the recycling and retrograde flow of actin filaments (Galisteo et al. 1996, Fan et al. 2003).
Literature References
PubMed ID Title Journal Year
8798379 The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

Schlessinger, J, Galisteo, ML, Skolnik, EY, Chernoff, J, Su, YC

J Biol Chem 1996
14527437 Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline

Fan, X, Bashaw, GJ, Hing, H, Labrador, JP

Neuron 2003
Participants
Input
Output
Orthologous Events
Recruitment of PAK to NCK (Homo sapiens)
Authored
Garapati, P V  (2008-09-05)
Reviewed
Jaworski, A  (2017-07-31)
Kidd, T  (2009-08-18)
Created
Garapati, P V  (2009-07-06)
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