Vilse binds Robo1:Slit2

Stable Identifier
R-DME-428529
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Vilse binds Robo1:Slit2
Vilse/CrossGAP (CrGAP), a conserved Rac-specific GAP in Drosophila, is involved in Robo mediated repulsion. CrGAP directly interacts with Robo, both biochemically and genetically. The biochemical interaction is mediated by the WW domains in CrGAP and the CC2 motif of Robo (Lundstrom et al. 2004, Hu et al. 2005).
Literature References
PubMed ID Title Journal Year
15342493 Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons

Lundström, A, Hemphälä, J, Keleman, K, Steneberg, P, Gallio, M, Aspenström, P, Falileeva, L, Samakovlis, C, Englund, C, Dickson, BJ

Genes Dev 2004
15755809 Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion

Li, M, Bashaw, GJ, Goodman, CS, Lai, EC, McEwen, J, Hu, H, Labrador, JP

Proc Natl Acad Sci U S A 2005
Participants
Input
Output
Orthologous Events
ARHGAP39 (Vilse) binds ROBO1:SLIT2 (Homo sapiens)
Authored
Garapati, P V  (2008-09-05)
Reviewed
Jaworski, A  (2017-07-31)
Kidd, T  (2009-08-18)
Created
Garapati, P V  (2009-07-06)
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