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RtGEF [cytosol]
Stable Identifier
R-DME-430346
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
ARHGEF7, A8DZ19
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
EPH-Ephrin signaling (Drosophila melanogaster)
Ephrin signaling (Drosophila melanogaster)
GIT1 binds bPIX (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
PAK binds RAC and bPIX (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
PAKs autophosphorylate (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
PAKs phosphorylate MLC (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
bPIX exchanges GTP for GDP on RAC, activating it (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
EGFR downregulation (Drosophila melanogaster)
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Drosophila melanogaster)
Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Drosophila melanogaster)
Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Drosophila melanogaster)
Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
CDC42:GTP binds CBL:Beta-Pix (Drosophila melanogaster)
Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Drosophila melanogaster)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Drosophila melanogaster)
Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Drosophila melanogaster)
Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase cycle (Drosophila melanogaster)
RHOA GTPase cycle (Drosophila melanogaster)
RHOA GEFs activate RHOA (Drosophila melanogaster)
RHOA GEFs [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
RHOQ GTPase cycle (Drosophila melanogaster)
RHOQ binds effectors at the plasma membrane (Drosophila melanogaster)
RHOQ effectors [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Drosophila melanogaster)
RHOQ effectors [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
RHOV GTPase cycle (Drosophila melanogaster)
RHOV binds effectors at the plasma membrane (Drosophila melanogaster)
RHOV effectors [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
RHOV:GTP:RHOV effectors [plasma membrane] (Drosophila melanogaster)
RHOV effectors [cytosol] (Drosophila melanogaster)
RtGEF [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:A8DZ19
Gene Names
RtGEF
Reference Genes
BioGPS Gene:35306 RtGEF
ENSEMBL:FBgn0015803
FlyBase:FBgn0015803
KEGG:dme:Dmel_CG10043 RtGEF
Monarch:35306 RtGEF
NCBI Gene:35306 RtGEF
UCSC:A8DZ19 RtGEF
Reference Transcript
RefSeq:NM_001103714.3 RtGEF
Other Identifiers
143847_at
1639115_s_at
35306
GO:0005085
GO:0005515
GO:0005737
GO:0016043
GO:0030027
GO:0035332
GO:0043226
GO:0043547
GO:0046621
GO:0050807
GO:0060090
GO:0097482
GO:0098772
Participates
as a candidate of
RHOA GEFs [cytosol] (Drosophila melanogaster)
RHOV effectors [cytosol] (Drosophila melanogaster)
RHOQ effectors [cytosol] (Drosophila melanogaster)
CDC42 effectors [cytosol] (Drosophila melanogaster)
RHOJ effectors [cytosol] (Drosophila melanogaster)
as an input of
GIT1 binds bPIX (Drosophila melanogaster)
as a component of
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Drosophila melanogaster)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
Other forms of this molecule
RtGEF [cytosol]
Inferred From
ARHGEF7 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001097184.2
ENSEMBL
FBtr0479856
,
FBtr0336747
,
FBpp0428192
,
FBpp0307723
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