CRY is activated by light and binds to cytosolic TIM

Stable Identifier
R-DME-432426
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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CRY is activated by light and binds to cytosolic TIM
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At dawn, a light-induced conformational change in the blue-light photoreceptor cryptochrome (CRY) promotes the formation of a complex with Timeless (TIM). In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for TIM degradation are the same. Also, in flies kept in constant darkness for many days, TIM levels still undergo daily oscillations, although not as robust as in light-dark cycles. The mechanism that drives daily cycles in TIM levels during extended periods in complete darkness is not clear.
Literature References
PubMed ID Title Journal Year
11585911 Photic signaling by cryptochrome in the Drosophila circadian system

Song, W, Lin, FJ, Naidoo, N, Sehgal, A, Meyer-Bernstein, E

Mol Cell Biol 2001
15178801 Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception

Emery, P, Emery-Le, M, Rosbash, M, Busza, A

Science 2004
10417378 Light-dependent sequestration of TIMELESS by CRYPTOCHROME

Petti, AA, Darlington, TK, Más, P, Weitz, CJ, Ceriani, MF, Staknis, D, Kay, SA

Science 1999
19185492 Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless

Peschel, N, Szabo, G, Stanewsky, R, Chen, KF

Curr Biol 2009
15258584 A constitutively active cryptochrome in Drosophila melanogaster

Kyriacou, CP, Fedic, R, Garner, KJ, Rosato, E, Costa, R, Dissel, S, Codd, V

Nat Neurosci 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

blue light photoreceptor activity of Photon [cytosol]

Physical Entity
Photon [cytosol]
Activity
blue light photoreceptor activity (GO:0009882)
Authored
Williams, MG  (2009-08-13)
Reviewed
Edery, I  (2010-07-06)
Created
Williams, MG  (2009-08-14)
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