Cytosolic TIM is degraded by the 26S proteasome

Stable Identifier
R-DME-432507
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Cytosolic TIM is degraded by the 26S proteasome
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Ubiquitinated phosphorylated Timeless (TIM) is degraded by the 26S proteasome.
Literature References
PubMed ID Title Journal Year
15178801 Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception

Emery, P, Emery-Le, M, Rosbash, M, Busza, A

Science 2004
16794082 JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS

Sehgal, A, Zheng, X, Koh, K

Science 2006
10481010 A role for the proteasome in the light response of the timeless clock protein

Song, W, Hunter-Ensor, M, Naidoo, N, Sehgal, A

Science 1999
19185492 Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless

Peschel, N, Szabo, G, Stanewsky, R, Chen, KF

Curr Biol 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Drosophila melanogaster)
Activity
endopeptidase activity (GO:0004175)
Authored
Williams, MG  (2009-08-13)
Reviewed
Edery, I  (2010-07-06)
Created
Williams, MG  (2009-08-14)
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